Evidence map›Paper›PMID 36943313›Full record

ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2023

The Substitution of Fifty Percent of Combustible Tobacco Smoke Exposure With Either Electronic Cigarettes or Heated tobacco Products Did Not Attenuate Acute Lung Injury in an Animal Model.

Ahmad Husari, Mohammad El-Harakeh, Alan Shihadeh, Michella Abi Zeid Daou, Hala Bitar, Nareg Karaoghlanian, Ghazi Zaatari, Marwan El-Sabban

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Review
  5. Article
  6. Electronic Cigarette Harms: Aggregate Evidence Shows Damage to Biological Systems.International journal of environmental research and public health · 2023
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ahmad HusariDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine; American University of Beirut, Beirut, Lebanon.ORCID 0000-0002-2317-1385
Mohammad El-HarakehDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine; American University of Beirut, Beirut, Lebanon.ORCID 0000-0003-3014-3937
Alan ShihadehDepartment of Mechanical Engineering, American University of Beirut, Beirut, Lebanon.
Michella Abi Zeid DaouDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine; American University of Beirut, Beirut, Lebanon.
Hala BitarDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine; American University of Beirut, Beirut, Lebanon.
Nareg KaraoghlanianDepartment of Mechanical Engineering, American University of Beirut, Beirut, Lebanon.ORCID 0000-0002-3553-7233
Ghazi ZaatariDepartment of Pathology & Laboratory Medicine, American University of Beirut, Beirut, Lebanon.
Marwan El-SabbanDepartment of Anatomy, Cell Biology, and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
American University of Beirut · LBVirginia Commonwealth University · US

Funding

Training and Education Core p270-287P50DA036105 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI EISSENBERG, THOMAS EVAN · 2013 to 2017
$19.2M
NIDA NIH HHS P50 DA036105NIH HHS P50DA036105
6 · The paper itself

Abstract

backgroundTo reduce the harmful health effects of combustible cigarette smoke (CS), some (CS) users attempt to substitute CS with electronic cigarettes (ECIG) and/or heated tobacco products (HTP). In this animal study, we evaluated the acute effects of substituting CS consumption with ECIG or HTP thus mimicking the dual users' approach, on the lungs of a mouse model.

methodsC57BL/6 mice were divided into Control, ECIG, HTP, CS, ECIG + CS, HTP + CS, and HTP + ECIG groups. Animals were exposed for 3 hours in AM and PM sessions to either air, CS, ECIG, or HTP for seven days. Lung injury was assessed by: wet to dry (W/D) ratio, albumin concentration in bronchoalveolar lavage fluid, expression of IL-1β, IL-6, and TNF-α, histopathology examination, reactive oxygen species (ROS) production, and assessment of cellular apoptosis.

resultsW/D ratio was significantly increased in mice exposed to CS only. Albumin leak and expression of IL-1β, IL-6, and TNF-a were elevated in CS, ECIG + CS, and HTP + CS. Histological examination revealed significant inflammatory cells infiltration, as well as collagen deposit in CS, ECIG + CS, HTP + CS. ROS production was significantly increased in CS, ECIG + CS, HTP + CS. Finally, cell death was also significantly increased in CS, ECIG + CS, and HTP + CS.

conclusionIn this animal model, substituting 50% of daily CS exposure by either ECIG or HTP exposure did not result in significant attenuation of acute lung injury.

Indexed as

Acute Lung InjuryElectronic Nicotine Delivery SystemsTobacco ProductsTobacco Smoke PollutionAlbuminsAnimalsDisease Models, AnimalInterleukin-6MiceMice, Inbred C57BLReactive Oxygen SpeciesAlbuminsInterleukin-6Reactive Oxygen SpeciesTobacco Smoke Pollution

Identifiers

PMID36943313
PMCPMC10256882
OpenAlexW4328049146

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.