Evidence map›Paper›PMID 36943080›Full record

ArticleRadiology2023

Using Machine Learning to Reduce the Need for Contrast Agents in Breast MRI through Synthetic Images.

Gustav Müller-Franzes, Luisa Huck, Soroosh Tayebi Arasteh, Firas Khader, Tianyu Han, Volkmar Schulz, Ebba Dethlefsen, Jakob Nikolas Kather, Sven Nebelung, Teresa Nolte and 2 more

Abstract read
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In one paragraph

Article in Radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
14.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Review
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  5. Article
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  9. Acquisition of KQuantitative imaging in medicine and surgery · 2026
    Article
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  15. Article
  16. Clinical Application of Artificial Intelligence in Breast MRI.Journal of the Korean Society of Radiology · 2025
    Review
  17. Article
  18. Article
  19. AI Applications to Breast MRI: Today and Tomorrow.Journal of magnetic resonance imaging : JMRI · 2024
    Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Gustav Müller-FranzesFrom the Department of Diagnostic and Interventional Radiology (G.M.F., L.H., S.T.A., F.K., E.D., S.N., T.N., C.K., D.T.) and Department of Medicine III (J.N.K.), University Hospital RWTH Aachen, Pauwelsstrasse 30, Aachen 52074, Germany; and Department of Physics of Molecular Imaging Systems, Division of Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany (T.H., V.S.).ORCID 0000-0002-7413-2570
Luisa HuckFrom the Department of Diagnostic and Interventional Radiology (G.M.F., L.H., S.T.A., F.K., E.D., S.N., T.N., C.K., D.T.) and Department of Medicine III (J.N.K.), University Hospital RWTH Aachen, Pauwelsstrasse 30, Aachen 52074, Germany; and Department of Physics of Molecular Imaging Systems, Division of Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany (T.H., V.S.).ORCID 0000-0002-4898-4294
Soroosh Tayebi ArastehFrom the Department of Diagnostic and Interventional Radiology (G.M.F., L.H., S.T.A., F.K., E.D., S.N., T.N., C.K., D.T.) and Department of Medicine III (J.N.K.), University Hospital RWTH Aachen, Pauwelsstrasse 30, Aachen 52074, Germany; and Department of Physics of Molecular Imaging Systems, Division of Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany (T.H., V.S.).ORCID 0000-0003-1015-7733
Firas KhaderFrom the Department of Diagnostic and Interventional Radiology (G.M.F., L.H., S.T.A., F.K., E.D., S.N., T.N., C.K., D.T.) and Department of Medicine III (J.N.K.), University Hospital RWTH Aachen, Pauwelsstrasse 30, Aachen 52074, Germany; and Department of Physics of Molecular Imaging Systems, Division of Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany (T.H., V.S.).ORCID 0000-0001-5089-3589
Tianyu HanFrom the Department of Diagnostic and Interventional Radiology (G.M.F., L.H., S.T.A., F.K., E.D., S.N., T.N., C.K., D.T.) and Department of Medicine III (J.N.K.), University Hospital RWTH Aachen, Pauwelsstrasse 30, Aachen 52074, Germany; and Department of Physics of Molecular Imaging Systems, Division of Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany (T.H., V.S.).ORCID 0000-0002-8636-6462
Volkmar SchulzFrom the Department of Diagnostic and Interventional Radiology (G.M.F., L.H., S.T.A., F.K., E.D., S.N., T.N., C.K., D.T.) and Department of Medicine III (J.N.K.), University Hospital RWTH Aachen, Pauwelsstrasse 30, Aachen 52074, Germany; and Department of Physics of Molecular Imaging Systems, Division of Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany (T.H., V.S.).ORCID 0000-0003-1341-9356
Ebba DethlefsenFrom the Department of Diagnostic and Interventional Radiology (G.M.F., L.H., S.T.A., F.K., E.D., S.N., T.N., C.K., D.T.) and Department of Medicine III (J.N.K.), University Hospital RWTH Aachen, Pauwelsstrasse 30, Aachen 52074, Germany; and Department of Physics of Molecular Imaging Systems, Division of Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany (T.H., V.S.).ORCID 0009-0001-7677-4032
Jakob Nikolas KatherFrom the Department of Diagnostic and Interventional Radiology (G.M.F., L.H., S.T.A., F.K., E.D., S.N., T.N., C.K., D.T.) and Department of Medicine III (J.N.K.), University Hospital RWTH Aachen, Pauwelsstrasse 30, Aachen 52074, Germany; and Department of Physics of Molecular Imaging Systems, Division of Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany (T.H., V.S.).ORCID 0000-0002-3730-5348
Sven NebelungFrom the Department of Diagnostic and Interventional Radiology (G.M.F., L.H., S.T.A., F.K., E.D., S.N., T.N., C.K., D.T.) and Department of Medicine III (J.N.K.), University Hospital RWTH Aachen, Pauwelsstrasse 30, Aachen 52074, Germany; and Department of Physics of Molecular Imaging Systems, Division of Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany (T.H., V.S.).ORCID 0000-0002-5267-9962
Teresa NolteFrom the Department of Diagnostic and Interventional Radiology (G.M.F., L.H., S.T.A., F.K., E.D., S.N., T.N., C.K., D.T.) and Department of Medicine III (J.N.K.), University Hospital RWTH Aachen, Pauwelsstrasse 30, Aachen 52074, Germany; and Department of Physics of Molecular Imaging Systems, Division of Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany (T.H., V.S.).ORCID 0000-0003-3167-7121
Christiane Kuhl *From the Department of Diagnostic and Interventional Radiology (G.M.F., L.H., S.T.A., F.K., E.D., S.N., T.N., C.K., D.T.) and Department of Medicine III (J.N.K.), University Hospital RWTH Aachen, Pauwelsstrasse 30, Aachen 52074, Germany; and Department of Physics of Molecular Imaging Systems, Division of Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany (T.H., V.S.).ORCID 0000-0001-8696-2363
Daniel Truhn *From the Department of Diagnostic and Interventional Radiology (G.M.F., L.H., S.T.A., F.K., E.D., S.N., T.N., C.K., D.T.) and Department of Medicine III (J.N.K.), University Hospital RWTH Aachen, Pauwelsstrasse 30, Aachen 52074, Germany; and Department of Physics of Molecular Imaging Systems, Division of Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany (T.H., V.S.).ORCID 0000-0002-9605-0728
RWTH Aachen University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Reducing the amount of contrast agent needed for contrast-enhanced breast MRI is desirable. Purpose To investigate if generative adversarial networks (GANs) can recover contrast-enhanced breast MRI scans from unenhanced images and virtual low-contrast-enhanced images. Materials and Methods In this retrospective study of breast MRI performed from January 2010 to December 2019, simulated low-contrast images were produced by adding virtual noise to the existing contrast-enhanced images. GANs were then trained to recover the contrast-enhanced images from the simulated low-contrast images (approach A) or from the unenhanced T1- and T2-weighted images (approach B). Two experienced radiologists were tasked with distinguishing between real and synthesized contrast-enhanced images using both approaches. Image appearance and conspicuity of enhancing lesions on the real versus synthesized contrast-enhanced images were independently compared and rated on a five-point Likert scale.

Indexed as

Contrast MediaMagnetic Resonance ImagingBreastHumansMachine LearningMiddle AgedRetrospective StudiesContrast Media

Identifiers

PMID36943080
OpenAlexW4328048195

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.