ArticleRadiology2023
Normative Cerebral Hemodynamics in Middle-aged and Older Adults Using 4D Flow MRI: Initial Analysis of Vascular Aging.
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Article in Radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
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24 citing papers in PubMed, 35 citations in OpenAlex.
- Jointly Learned 3D Non-Cartesian Sampling With Wave Encoding and Reconstruction for Neurovascular Phase Contrast MRI.Magnetic resonance in medicine · 2026Article
- Cerebral Blood and Cerebrospinal Fluid Flow Dynamics in Endurance Athletes: Associations With Aortic Recoil and Heart Rate.Scandinavian journal of medicine & science in sports · 2026Article
- Simultaneous quantitative evaluation of both iliac arteries and veins via accelerated four-dimensional flow in healthy controls and patients with deep vein thrombosis: a pilot study.Quantitative imaging in medicine and surgery · 2026Article
- Altered cerebrovascular haemodynamics in Parkinson's disease: Insights from 4D flow MRI.NPJ Parkinson's disease · 2026Article
- Flow-based simulation in transverse sinus stenosis pre- and post-stenting: pressure prediction accuracy, hemodynamic complexity, and relationship to pulsatile tinnitus.Journal of neurointerventional surgery · 2026Article
- Investigating association of triglycerides with hemodynamic parameters in patients with Low cardiovascular risk using 4D flow MRI.Frontiers in cardiovascular medicine · 2026Article
- Advantages of integrating artificial intelligence and spectral CT for lung nodule classification and prognostic judgment: a narrative review.Journal of thoracic disease · 2025Review
- Repeatability and reproducibility of hemodynamic measurements by intracranial 4D Flow MRI: a multi‑vendor and multi‑software cross‑over comparison study.BMC medical imaging · 2025Article
- Arterial-optimized 4D-flow MRI for quantifying flow and pulsatility in venous sinuses and large cerebral veins.Scientific reports · 2025Article
- A novel early imaging biomarker for glymphatic function: Cerebral cortical arterial pulsatility index from 2-Minute phase-contrast MRI.The journal of prevention of Alzheimer's disease · 2025Article
- Biological sex influences relationships between cerebral pulsatility and white matter hyperintensities in aging adults.American journal of physiology. Heart and circulatory physiology · 2025Article
- Intracranial pulse wave velocity using 4D flow MRI: method comparison and covariate analysis.Interface focus · 2025Article
- Transmantle pressure under the influence of free breathing: non-invasive quantification of the aqueduct pressure gradient in healthy adults.Fluids and barriers of the CNS · 2025Article
- Sex differences in sleep apnea and Alzheimer's Disease: role of cerebrovascular dysfunction.npj women's health · 2025Review
- Association between carotid artery hemodynamics and neurovascular coupling in cerebral small vessel disease: an exploratory study.Frontiers in aging neuroscience · 2025Article
- Simultaneous and synchronous characterization of blood and CSF flow dynamics using multiple Venc PC MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Aging and Sex Differences in Brain Volume and Cerebral Blood Flow.Aging and disease · 2024Article
- Unraveling diurnal and technical variability in cerebral hemodynamics from neurovascular 4D-Flow MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Four-dimensional flow MRI for quantitative assessment of cerebrospinal fluid dynamics: Status and opportunities.NMR in biomedicine · 2024Review
- Measuring global cerebrovascular pulsatility transmission using 4D flow MRI.Scientific reports · 2024Article
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Authors and funding
12 authors at 1 institution in 1 country.
Grant S RobertsFrom the Department of Medical Physics (G.S.R., L.A.R.R., O.W., K.M.J.), Department of Radiology (A.P., C.A.H., H.A.R., O.W., K.M.J., L.B.E.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., S.C.J.), and Wisconsin Alzheimer's Disease Research Center (E.M.J., L.A.R.R., K.A.C., S.C.J.), University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792-3252; and Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wis (S.C.J.).ORCID 0000-0003-1472-4352
Anthony PeretFrom the Department of Medical Physics (G.S.R., L.A.R.R., O.W., K.M.J.), Department of Radiology (A.P., C.A.H., H.A.R., O.W., K.M.J., L.B.E.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., S.C.J.), and Wisconsin Alzheimer's Disease Research Center (E.M.J., L.A.R.R., K.A.C., S.C.J.), University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792-3252; and Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wis (S.C.J.).
Erin M JonaitisFrom the Department of Medical Physics (G.S.R., L.A.R.R., O.W., K.M.J.), Department of Radiology (A.P., C.A.H., H.A.R., O.W., K.M.J., L.B.E.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., S.C.J.), and Wisconsin Alzheimer's Disease Research Center (E.M.J., L.A.R.R., K.A.C., S.C.J.), University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792-3252; and Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wis (S.C.J.).
Rebecca L KoscikFrom the Department of Medical Physics (G.S.R., L.A.R.R., O.W., K.M.J.), Department of Radiology (A.P., C.A.H., H.A.R., O.W., K.M.J., L.B.E.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., S.C.J.), and Wisconsin Alzheimer's Disease Research Center (E.M.J., L.A.R.R., K.A.C., S.C.J.), University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792-3252; and Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wis (S.C.J.).ORCID 0000-0003-0025-744X
Carson A HoffmanFrom the Department of Medical Physics (G.S.R., L.A.R.R., O.W., K.M.J.), Department of Radiology (A.P., C.A.H., H.A.R., O.W., K.M.J., L.B.E.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., S.C.J.), and Wisconsin Alzheimer's Disease Research Center (E.M.J., L.A.R.R., K.A.C., S.C.J.), University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792-3252; and Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wis (S.C.J.).
Leonardo A Rivera-RiveraFrom the Department of Medical Physics (G.S.R., L.A.R.R., O.W., K.M.J.), Department of Radiology (A.P., C.A.H., H.A.R., O.W., K.M.J., L.B.E.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., S.C.J.), and Wisconsin Alzheimer's Disease Research Center (E.M.J., L.A.R.R., K.A.C., S.C.J.), University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792-3252; and Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wis (S.C.J.).ORCID 0000-0001-5629-8721
Karly A CodyFrom the Department of Medical Physics (G.S.R., L.A.R.R., O.W., K.M.J.), Department of Radiology (A.P., C.A.H., H.A.R., O.W., K.M.J., L.B.E.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., S.C.J.), and Wisconsin Alzheimer's Disease Research Center (E.M.J., L.A.R.R., K.A.C., S.C.J.), University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792-3252; and Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wis (S.C.J.).
Howard A RowleyFrom the Department of Medical Physics (G.S.R., L.A.R.R., O.W., K.M.J.), Department of Radiology (A.P., C.A.H., H.A.R., O.W., K.M.J., L.B.E.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., S.C.J.), and Wisconsin Alzheimer's Disease Research Center (E.M.J., L.A.R.R., K.A.C., S.C.J.), University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792-3252; and Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wis (S.C.J.).ORCID 0000-0002-3235-5792
Sterling C JohnsonFrom the Department of Medical Physics (G.S.R., L.A.R.R., O.W., K.M.J.), Department of Radiology (A.P., C.A.H., H.A.R., O.W., K.M.J., L.B.E.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., S.C.J.), and Wisconsin Alzheimer's Disease Research Center (E.M.J., L.A.R.R., K.A.C., S.C.J.), University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792-3252; and Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wis (S.C.J.).
Oliver WiebenFrom the Department of Medical Physics (G.S.R., L.A.R.R., O.W., K.M.J.), Department of Radiology (A.P., C.A.H., H.A.R., O.W., K.M.J., L.B.E.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., S.C.J.), and Wisconsin Alzheimer's Disease Research Center (E.M.J., L.A.R.R., K.A.C., S.C.J.), University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792-3252; and Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wis (S.C.J.).ORCID 0000-0002-7931-1930
Kevin M JohnsonFrom the Department of Medical Physics (G.S.R., L.A.R.R., O.W., K.M.J.), Department of Radiology (A.P., C.A.H., H.A.R., O.W., K.M.J., L.B.E.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., S.C.J.), and Wisconsin Alzheimer's Disease Research Center (E.M.J., L.A.R.R., K.A.C., S.C.J.), University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792-3252; and Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wis (S.C.J.).ORCID 0000-0002-8660-0853
Laura B EisenmengerFrom the Department of Medical Physics (G.S.R., L.A.R.R., O.W., K.M.J.), Department of Radiology (A.P., C.A.H., H.A.R., O.W., K.M.J., L.B.E.), Wisconsin Alzheimer's Institute (E.M.J., R.L.K., S.C.J.), and Wisconsin Alzheimer's Disease Research Center (E.M.J., L.A.R.R., K.A.C., S.C.J.), University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792-3252; and Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wis (S.C.J.).ORCID 0000-0001-6764-4239
MACOM (United States) · US
Funding
University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9MWisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Barbara Brigitta Bendlin · 2019 to 2026
$34.5MWisconsin Registry for Alzheimer's PreventionRF1AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI JOHNSON, STERLING C · 2018 to 2018
$18.8MInstitutional Career Development CoreKL2TR002374 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI Bo Liu, Marin Leigh Schweizer · 2017 to 2026
$9.7MNRSA Training CoreTL1TR002375 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI Vivek Prabhakaran · 2017 to 2026
$8.4MNon-Invasive Imaging Markers to Elicit the Role of Vascular Involvement in Alzheimer’s DiseaseR01AG075788 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Kevin Michael Johnson · 2022 to 2026
$3.2MCharacterizing the Effect of Altered CSF and Blood Flow Dynamics on Alzheimer’s Disease Proteinopathy, Brain Health, and CognitionR21AG077337 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI RIVERA RIVERA, LEONARDO A · 2022 to 2022
$428kMulti-Parametric Imaging of Systemic Cardiovascular and Cerebrovascular Health in Alzheimer's DiseaseF31AG071183 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI ROBERTS, GRANT S. · 2021 to 2022
$70kNCATS NIH HHS KL2 TR002374NCATS NIH HHS TL1 TR002375NCATS NIH HHS UL1 TR002373NIA NIH HHS F31 AG071183NIA NIH HHS P30 AG062715NIA NIH HHS R01 AG075788NIA NIH HHS R21 AG077337NIA NIH HHS RF1 AG027161
Abstract
Background Characterizing cerebrovascular hemodynamics in older adults is important for identifying disease and understanding normal neurovascular aging. Four-dimensional (4D) flow MRI allows for a comprehensive assessment of cerebral hemodynamics in a single acquisition. Purpose To establish reference intracranial blood flow and pulsatility index values in a large cross-sectional sample of middle-aged (45-65 years) and older (>65 years) adults and characterize the effect of age and sex on blood flow and pulsatility. Materials and Methods In this retrospective study, patients aged 45-93 years (cognitively unimpaired) underwent cranial 4D flow MRI between March 2010 and March 2020. Blood flow rates and pulsatility indexes from 13 major arteries and four venous sinuses and total cerebral blood flow were collected. Intraobserver and interobserver reproducibility of flow and pulsatility measures was assessed in 30 patients. Descriptive statistics (mean ± SD) of blood flow and pulsatility were tabulated for the entire group and by age and sex. Multiple linear regression and linear mixed-effects models were used to assess the effect of age and sex on total cerebral blood flow and vessel-specific flow and pulsatility, respectively. Results There were 759 patients (mean age, 65 years ± 8 [SD]; 506 female patients) analyzed. For intra- and interobserver reproducibility, median intraclass correlation coefficients were greater than 0.90 for flow and pulsatility measures across all vessels. Regression coefficients β ± standard error from multiple linear regression showed a 4 mL/min decrease in total cerebral blood flow each year (age β = -3.94 mL/min per year ± 0.44;
Indexed as
Cerebral ArteriesCerebrovascular CirculationCranial SinusesHemodynamicsMagnetic Resonance ImagingAgedAged, 80 and overAgingBlood Flow VelocityCross-Sectional StudiesFemaleHumansMaleMiddle AgedRetrospective Studies
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