Evidence map›Paper›PMID 36942942›Full record

ArticleeLife2023

The Slingshot phosphatase 2 is required for acrosome biogenesis during spermatogenesis in mice.

Ke Xu, Xianwei Su, Kailun Fang, Yue Lv, Tao Huang, Mengjing Li, Ziqi Wang, Yingying Yin, Tahir Muhammad, Shangming Liu and 8 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 4 countries.

Ke Xu *Center for Reproductive Medicine, Shandong University, Jinan, China.
Xianwei Su *CUHK-SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, China.
Kailun Fang *Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0003-2456-6423
Yue LvCUHK-SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, China.
Tao HuangCenter for Reproductive Medicine, Shandong University, Jinan, China.ORCID 0000-0002-7086-570X
Mengjing LiCenter for Reproductive Medicine, Shandong University, Jinan, China.
Ziqi WangCenter for Reproductive Medicine, Shandong University, Jinan, China.
Yingying YinCenter for Reproductive Medicine, Shandong University, Jinan, China.
Tahir MuhammadCenter for Reproductive Medicine, Shandong University, Jinan, China.
Shangming LiuSchool of Basic Medical Sciences, Shandong University, Jinan, China.
Xiangfeng ChenShanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China.
Jing JiangGenome Tagging Project (GTP) Center, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.
Jinsong LiGenome Tagging Project (GTP) Center, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0003-3456-662X
Wai-Yee ChanCenter for Reproductive Medicine, Shandong University, Jinan, China.
Jinlong MaCenter for Reproductive Medicine, Shandong University, Jinan, China.
Gang LuCenter for Reproductive Medicine, Shandong University, Jinan, China.
Zi-Jiang ChenCenter for Reproductive Medicine, Shandong University, Jinan, China.ORCID 0000-0001-6637-6631
Hongbin LiuCenter for Reproductive Medicine, Shandong University, Jinan, China.ORCID 0000-0003-2550-7492
Shandong University · CNChinese Academy of Sciences · CNChinese University of Hong Kong · HKCARE Fertility · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The acrosome is a membranous organelle positioned in the anterior portion of the sperm head and is essential for male fertility. Acrosome biogenesis requires the dynamic cytoskeletal shuttling of vesicles toward nascent acrosome which is regulated by a series of accessory proteins. However, much remains unknown about the molecular basis underlying this process. Here, we generated

Indexed as

AcrosomeActinsActin Depolymerizing FactorsAnimalsMaleMiceMice, KnockoutSemenSpermatogenesisActin Depolymerizing FactorsActinsacrosome biogenesisactin remodelingdevelopmental biologymousespermatogenesisSsh2

Identifiers

PMID36942942
PMCPMC10065795
OpenAlexW4328049679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.