ArticlePest management science2023
Insecticide resistance compromises the control of Aedes aegypti in Bangladesh.
Article in Pest management science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Epidemiological Trends, Public Health Challenges, and Strategic Control Priorities of Dengue in Bangladesh (2000-2024): A Narrative Review.Health science reports · 2026Article
- Molecular xenosurveillance ofMicrobiology spectrum · 2025Article
- Dengue fever in Bangladesh: rising trends, contributing factors, and public health implications.Tropical diseases, travel medicine and vaccines · 2025Review
- Association of knockdown resistance mutations with pyrethroid resistance in Aedes aegypti, a major arbovirus vector in Cameroon.Parasites & vectors · 2025Article
- Small mosquitoes: large implications-effects of larval crowding and starvation on locomotor activity, adult biting frequency, and insecticide resistance in two strains of Aedes aegypti.Parasites & vectors · 2025Article
- Cytochrome P450 and esterase genes associated with permethrin resistance in Aedes aegypti (Linnaeus, 1762).Molecular biology reports · 2025Article
- Characterization of the transcriptional cellular response in midgut tissue of temephos-resistant Aedes aegypti larvae.Parasites & vectors · 2025Article
- Fitness compatibility and dengue virus Inhibition in a Bangladeshi strain of Aedes aegypti infected with the Wolbachia strain wAlbB.Scientific reports · 2025Article
- Entomological surveys and insecticide susceptibility profile of Aedes aegypti during the dengue outbreak in Sao Tome and Principe in 2022.PLoS neglected tropical diseases · 2024Article
- Comparative biotoxicity study for identifying better alternative insecticide especially green nano-emulsion which used as mosquitocides.BMC veterinary research · 2024Article
- Development and characterization of potential larvicidal nanoemulsions againstBeilstein journal of nanotechnology · 2024Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundWith no effective drugs or widely available vaccines, dengue control in Bangladesh is dependent on targeting the primary vector Aedes aegypti with insecticides and larval source management. Despite these interventions, the dengue burden is increasing in Bangladesh, and the country experienced its worst outbreak in 2019 with 101 354 hospitalized cases. This may be partially facilitated by the presence of intense insecticide resistance in vector populations. Here, we describe the intensity and mechanisms of resistance to insecticides commonly deployed against Ae. aegypti in Dhaka, Bangladesh.
resultsDhaka Ae. aegypti colonies exhibited high-intensity resistance to pyrethroids. Using CDC bottle assays, we recorded 2-24% mortality (recorded at 24 h) to permethrin and 48-94% mortality to deltamethrin, at 10× the diagnostic dose. Bioassays conducted using insecticide-synergist combinations suggested that metabolic mechanisms were contributing to pyrethroid resistance, specifically multi-function oxidases, esterases, and glutathione S-transferases. In addition, kdr alleles were detected, with a high frequency (78-98%) of homozygotes for the V1016G mutation. A large proportion (≤ 74%) of free-flying and resting mosquitoes from Dhaka colonies survived exposure to standard applications of pyrethroid aerosols in an experimental free-flight room. Although that exposure affected the immediate host-seeking behavior of Ae. aegypti, the effect was transient in surviving mosquitoes.
conclusionThe intense resistance characterized in this study is likely compromising the operational effectiveness of pyrethroids against Ae. aegypti in Dhaka. Switching to alternative chemical classes may offer a medium-term solution, but ultimately a more sustainable and effective approach to controlling dengue vectors is required. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
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