Evidence map›Paper›PMID 36942548›Full record

ArticleThe neuroradiology journal2023

Volumetric differences of thalamic nuclei in children with trisomy 21.

Matthias W Wagner, Nirit Bernhard, Gopolang Mndebele, Logi Vidarsson, Birgit B Ertl-Wagner

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The neuroradiology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Structural MRI across lifespan reveals differential thalamic trajectories in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Matthias W WagnerDepartment of Diagnostic Imaging, Division of Neuroradiology, The Hospital for Sick Children, Department of Medical Imaging, University of Toronto, Toronto, Canada.ORCID 0000-0001-6501-839X
Nirit BernhardThe Hospital for Sick Children Department of Paediatrics, University of Toronto, Toronto, Canada.
Gopolang MndebeleDepartment of Diagnostic Imaging, Division of Neuroradiology, The Hospital for Sick Children, Department of Medical Imaging, University of Toronto, Toronto, Canada.
Logi VidarssonDepartment of Diagnostic Imaging, Division of Neuroradiology, The Hospital for Sick Children, Department of Medical Imaging, University of Toronto, Toronto, Canada.
Birgit B Ertl-WagnerDepartment of Diagnostic Imaging, Division of Neuroradiology, The Hospital for Sick Children, Department of Medical Imaging, University of Toronto, Toronto, Canada.
University of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesHistological studies have shown alterations of thalamic nuclei in patients with Down syndrome (DS). The correlation of these changes on MRI (magnetic resonance imaging) is unclear. Therefore, this study investigates volumetric differences of thalamic nuclei in children with DS compared to controls.

methodsPatients were retrospectively identified between 01/2000 and 10/2021. Patient inclusion criteria were: (1) 0-18 years of age, (2) diagnosis of DS, and (3) availability of a brain MRI without parenchymal injury and a non-motion-degraded volumetric T1-weighted sequence. Whole thalamus and thalamic nuclei (

results21 children with DS (11 females, 52.4%, mean age: 8.6 ± 4.3 years) and 63 age- and sex-matched controls (32 females, 50.8%, 8.6 ± 4.3 years) were studied using automated volumetric segmentation. Significantly smaller ratios were found for nine thalamic nuclei and the whole thalamus on the right and five thalamic nuclei on the left. TBV was significantly smaller in patients with DS (

conclusionsIn this exploratory volumetric analysis of the thalamus and thalamic nuclei, we observed statistically significant volumetric changes in children with DS. Our findings confirm prior neuroimaging and histological studies and extend the range of involved thalamic nuclei in pediatric DS.

Indexed as

Down SyndromeMagnetic Resonance ImagingThalamic NucleiAdolescentCase-Control StudiesChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleOrgan SizeRetrospective StudieschildrenDown syndromeFreeSurfermagnetic resonance imagingthalamus

Identifiers

PMID36942548
PMCPMC10569191
OpenAlexW4328048524

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.