Evidence map›Paper›PMID 36942067›Full record

ArticleIranian journal of pharmaceutical research : IJPR2022

Isolation of the Anticoagulant and Procoagulant Fractions of the Venom of Iranian Endemic

Nafiseh Nasri Nasrabadi, Nasser Mohammadpour Dounighi, Minoo Ahmadinejad, Hadi Rabiei, Maryam Tabarzad, Mojtaba Najafi, Hossein Vatanpour

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian journal of pharmaceutical research : IJPR, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Nafiseh Nasri NasrabadiStudent Research Commitee, Pharmaceutical Sciences Research Centre, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0003-3801-2632
Nasser Mohammadpour DounighiDepartment of Venomous Animals and Anti-venom Production, Razi Vaccine and Serum Research Institute, Karaj, Iran.
Minoo AhmadinejadPathology Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
Hadi RabieiDepartment of Venomous Animals and Anti-venom Production, Razi Vaccine and Serum Research Institute, Karaj, Iran.
Maryam TabarzadProtein Technology Research Center, Shahid Behashti University of Medical Sciences, Tehran, Iran.
Mojtaba NajafiGorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.
Hossein VatanpourDepartment of Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Razi Vaccine and Serum Research Institute · IRShahid Beheshti University of Medical Sciences · IRGorgan University of Agricultural Sciences and Natural Resources · IRHigh Institute for Education and Research in Transfusion Medicine · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The venom of Objectives: The present study focuses on setting up a procedure for the purification of crude venom and designing appropriate clotting tests in order to characterize the procoagulant and anticoagulant fractions of Methods: Chromatographic methods, including gel filtration, ion-exchange chromatography, and reverse-phase high-performance liquid chromatography (HPLC), were applied for purifying these fractions. Coagulant activity testing, prothrombin time (PT), and activated partial thromboplastin time (APTT) were used to determine procoagulant and anticoagulant properties. For measuring molecular weight, 15% SDS-PAGE electrophoresis with a molecular weight standard ranging from 6.5 to 200 kDa was used. Results: We obtained five fractions named F Conclusions: Our findings suggest an efficient and suitable procedure for the identification and purification of the procoagulant and anticoagulant factors of the venom of Iranian

Indexed as

Anti-coagulantIranian Echis carinatusPro-coagulant

Identifiers

PMID36942067
PMCPMC10024320
OpenAlexW4293322290

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.