Evidence map›Paper›PMID 36941580›Full record

ReviewJournal of inflammation (London, England)2023

Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance.

Gaetano Scaramuzzo, Francesco Nucera, Alessio Asmundo, Roberto Messina, Matilde Mari, Federica Montanaro, Matt D Johansen, Francesco Monaco, Guido Fadda, Giovanni Tuccari and 9 more

Open access · goldFull text readReview
In one paragraph

Review in Journal of inflammation (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 3 countries.

Gaetano Scaramuzzo *Department of Translational Medicine, University of Ferrara, Ferrara, Italy.ORCID http://orcid.org/0000-0001-9739-4082
Francesco Nucera *Pneumologia, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università di Messina, Messina, Italy.ORCID http://orcid.org/0000-0001-8454-5363
Alessio AsmundoMedicina Legale, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università di Messina, Messina, Italy.ORCID http://orcid.org/0000-0002-3159-7095
Roberto MessinaIntensive Care Unit, Dipartimento di Patologia Umana e dell'Età Evolutiva Gaetano Barresi, Università di Messina, Messina, Italy.
Matilde MariDepartment of Translational Medicine, University of Ferrara, Ferrara, Italy.
Federica MontanaroDepartment of Translational Medicine, University of Ferrara, Ferrara, Italy.ORCID http://orcid.org/0000-0003-0278-661X
Matt D JohansenCentre for Inflammation, School of Life Sciences, Faculty of Science, Centenary Institute and University of Technology Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0001-5553-5270
Francesco MonacoChirurgia Toracica, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università di Messina, Messina, Italy.ORCID http://orcid.org/0000-0002-5617-7943
Guido FaddaSection of Pathological Anatomy, Department of Human Pathology of Adult and Developmental Age "Gaetano Barresi", University of Messina, Messina, Italy.ORCID http://orcid.org/0000-0001-9736-0544
Giovanni TuccariSection of Pathological Anatomy, Department of Human Pathology of Adult and Developmental Age "Gaetano Barresi", University of Messina, Messina, Italy.ORCID http://orcid.org/0000-0002-1561-4246
Nicole G HansbroCentre for Inflammation, School of Life Sciences, Faculty of Science, Centenary Institute and University of Technology Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-2371-7990
Philip M HansbroCentre for Inflammation, School of Life Sciences, Faculty of Science, Centenary Institute and University of Technology Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-4741-3035
Trevor T HanselMedical Research Council and Asthma, UK Centre in Allergic Mechanisms of Asthma, London, UK.ORCID http://orcid.org/0000-0003-3786-8105
Ian M AdcockAirway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK.ORCID http://orcid.org/0000-0003-2101-8843
Antonio DavidIntensive Care Unit, Dipartimento di Patologia Umana e dell'Età Evolutiva Gaetano Barresi, Università di Messina, Messina, Italy.ORCID http://orcid.org/0000-0003-4974-8186
Paul KirkhamDepartment of Biomedical Sciences, Faculty of Sciences and Engineering, University of Wolverhampton, West Midlands, Wolverhampton, UK.ORCID http://orcid.org/0000-0002-2575-2474
Gaetano CaramoriPneumologia, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università di Messina, Messina, Italy. gcaramori@unime.it.ORCID http://orcid.org/0000-0002-9807-327X
Carlo Alberto VoltaDepartment of Translational Medicine, University of Ferrara, Ferrara, Italy.ORCID http://orcid.org/0000-0003-3533-6121
Savino SpadaroDepartment of Translational Medicine, University of Ferrara, Ferrara, Italy.ORCID http://orcid.org/0000-0001-5027-5318
University of Messina · ITUniversity of Ferrara · ITUniversity of Technology Sydney · AUAsthma UK · GBImperial College London · GBUniversity of Wolverhampton · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and death is represented by acute (or acute on chronic) respiratory failure and acute respiratory distress syndrome (ARDS), often requiring hospital admission and ventilator support.The molecular pathogenesis of COVID-19-related ARDS (by now termed c-ARDS) is still poorly understood. In this review we will discuss the genetic susceptibility to COVID-19, the pathogenesis and the local and systemic biomarkers correlated with c-ARDS and the therapeutic options that target the cell signalling pathways of c-ARDS.

Indexed as

ARDSBiomarkersChemokinesCOVID-19CytokinesSARS-CoV-2

Identifiers

PMID36941580
PMCPMC10027286
OpenAlexW4328049066

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read59
identifiers read14
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.