Evidence map›Paper›PMID 36941544›Full record

ArticleBMC genomics2023

No association of a Vascular endothelial growth factor A (VEGFA) gene polymorphism with pre-eclampsia among pregnant women in Uganda.

Sheila Nabweyambo, Stephen Kanyerezi, John H-O Petterson, Fred Ashaba Katabazi, Alfred Ssekagiri, Savannah Mwesigwa, Gerald Mboowa, Faith Nakazzi, Annette Keesiga, Moses Adroma and 4 more

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In one paragraph

Article in BMC genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 4 countries.

Sheila NabweyamboDepartment of Medical Microbiology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda. nabweyambosheila@gmail.com.
Stephen KanyereziThe African Center of Excellence in Bioinformatics and Data-Intensive Sciences, Infectious Diseases Institute, Makerere University, Kampala, Uganda.
John H-O PettersonDepartment of Medical Biochemistry and Microbiology, Zoonosis Science Center, University of Uppsala, Uppsala, Sweden.
Fred Ashaba KatabaziMedical and Molecular Laboratory, College of Health Sciences, Makerere University, Kampala, Uganda.
Alfred SsekagiriDepartment of Immunology and Molecular Biology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda.
Savannah MwesigwaDepartment of Immunology and Molecular Biology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda.
Gerald MboowaThe African Center of Excellence in Bioinformatics and Data-Intensive Sciences, Infectious Diseases Institute, Makerere University, Kampala, Uganda.
Faith NakazziMedical and Molecular Laboratory, College of Health Sciences, Makerere University, Kampala, Uganda.
Annette KeesigaDepartment of Obstetrics and Gynaecology, Kawempe National Referral Hospital, Kampala, Uganda.
Moses AdromaDepartment of Obstetrics and Gynaecology, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.
Freddie BwangaDepartment of Medical Microbiology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda.
Naomi McGovernDepartment of Pathology, University of Cambridge, Tennis Court Road, Cambridge, UK.
Obondo James SandeDepartment of Immunology and Molecular Biology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda.
Annettee NakimuliDepartment of Obstetrics and Gynaecology, Kawempe National Referral Hospital, Kampala, Uganda.
Makerere University · UGInfectious Diseases Institute · UGUniversity of Cambridge · GBUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVascular endothelial growth factor A (VEGFA) is a major angiogenic factor that plays an important role in the formation of blood vessels during embryonic development. VEGFA has been implicated in the pathophysiology of pre-eclampsia (PE), since pre-eclamptic women present with reduced levels of free circulating VEGFA. The 3' untranslated region (3'-UTR) of the VEGFA gene consists of elements that regulate the transcription and hence expression of the VEGFA protein in circulation. Hence it is suggested that variations thereof could underlie the reduced VEGFA levels observed in pre-eclamptic women. The purpose of this study was to investigate presence of the + 936C/T polymorphism, a common single nucleotide polymorphism (SNP) in the 3'-UTR of the VEGFA gene, and determine its association with PE among pregnant women in Uganda.

resultsThere was no significant difference observed in the allele and genotype frequencies of the + 936C/T 3' UTR-VEGFA polymorphism between pre-eclamptic and normotensive pregnant women (P > 0.05). Additionally, there was no significant difference in the median plasma levels of free VEGFA among women with the wild type, CT and TT genotypes of the + 936C/T VEGFA polymorphism (median = 0.84 pg/mL (IQR = 0.39-1.41) Vs 1.05 (0.61-1.18) Vs 1.05 (1.05-1.05) respectively, p-value = 0.7161).

conclusionsThese study findings indicate that the + 936C/T 3' UTR-VEGFA polymorphism had no significant association with increased susceptibility to PE among women in Uganda. Further studies with a larger sample size are recommended.

Indexed as

Pre-Eclampsia3' Untranslated RegionsCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeHumansPolymorphism, Single NucleotidePregnancyPregnant PeopleUgandaVascular Endothelial Growth Factor A3' Untranslated RegionsVascular Endothelial Growth Factor AVEGFA protein, human3’ Untranslated regionAfricaGenetic biomarkersGenetic variationsPre-eclampsiaSanger sequencingSingle nucleotide polymorphismUgandaVascular endothelial growth factor

Identifiers

PMID36941544
PMCPMC10029258
OpenAlexW4328048339

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.