Evidence map›Paper›PMID 36941492›Full record

ArticleEuropean radiology2023

Correlations between intravoxel incoherent motion-derived fast diffusion and perfusion fraction parameters and VEGF- and MIB-1-positive rates in brain gliomas: an intraoperative MR-navigated, biopsy-based histopathologic study.

Yaru Sheng, Xuefei Dang, Hua Zhang, Wenting Rui, Jing Wang, Haixia Cheng, Tianming Qiu, Yong Zhang, Yueyue Ding, Zhenwei Yao and 2 more

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Article in European radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Yaru Sheng *Radiology Department of Huashan Hospital, Fudan University, Shanghai, 200040, China.
Xuefei Dang *Department of Oncology, Minhang Branch of Fudan University Shanghai Cancer Center, Shanghai, 200240, China.
Hua Zhang *Department of Radiology, the Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Wenting Rui *Radiology Department of Huashan Hospital, Fudan University, Shanghai, 200040, China.
Jing WangRadiology Department of Huashan Hospital, Fudan University, Shanghai, 200040, China.
Haixia ChengNeuropathology Department of Huashan Hospital, Fudan University, Shanghai, 200040, China.
Tianming QiuNeurosurgery Department of Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yong ZhangMR Research, GE Healthcare, 1 Huatuo Road, Shanghai, 201203, China.
Yueyue DingDepartment of Echocardiology, Children's Hospital, Suzhou University, Suzhou, 215000, China.
Zhenwei YaoRadiology Department of Huashan Hospital, Fudan University, Shanghai, 200040, China.
Haopeng Pang *Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, #197 Rui Jin Er Road, Shanghai, 200025, China. panghaopeng@126.com.
Yan Ren *Radiology Department of Huashan Hospital, Fudan University, Shanghai, 200040, China. renyan_richard@aliyun.com.ORCID http://orcid.org/0000-0001-5993-9248
Fudan University · CNFudan University Shanghai Cancer Center · CNQingdao University · CNShanghai Jiao Tong University · CNSoochow University · CNUnited Imaging Healthcare (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo explore the correlations between histopathologic findings and intravoxel incoherent motion (IVIM)-derived perfusion and diffusion parameters in brain gliomas.

methodsThirty-two biopsy samples from twenty-one patients with newly diagnosed gliomas from a previous prospective cohort study were retrospectively analyzed. All patients underwent diffusion-weighted MRI with 22 b values (0-5000 s/mm

resultsSignificant positive correlations were revealed between Dfast5000 and pVEGF (rho (r) = 0.466, p = 0.007), and Dfast1500 and pVEGF (r = 0.371, p = 0.037). A significant negative correlation was revealed between PF5000 with pMIB-1 (r =  - 0.456, p = 0.01). Moderate to good positive correlations were shown between Dfast5000 and glioma grades (r = 0.509, p = 0.003) and Dfast1500 and glioma grades (r = 0.476, p = 0.006).

conclusionsIVIM-DWI-derived Dfast and PF correlate, respectively, with intratumor pVEGF and pMIB-1. When using the wide-high b value scheme, IVIM-derived Dfast and PF tend to demonstrate better efficacy in evaluating malignancy-related characteristics such as angiogenesis and cellular proliferation in gliomas. KEY POINTS: • Intravoxel incoherent motion-diffusion-weighted imaging (IVIM-DWI)-derived fast diffusion (Dfast) and perfusion fraction (PF) can quantitatively reflect intratumor pVEGF and pMIB-1. • IVIM-DWI-derived Dfast and PF tend to demonstrate better efficacy in evaluating glioma malignancy when an optimized scheme is used. • IVIM-DWI-derived Dfast5000 and PF5000 are promising non-invasive parameters correlating with pVEGF and pMIB-1 in gliomas.

Indexed as

GliomaVascular Endothelial Growth Factor ABiopsyBrainCohort StudiesDiffusion Magnetic Resonance ImagingHumansKi-67 AntigenMotionPerfusionRetrospective StudiesKi-67 AntigenVascular Endothelial Growth Factor ABiopsyDiffusion magnetic resonance imagingGliomaKi-67 antigenVascular endothelial growth factor

Identifiers

PMID36941492
OpenAlexW4327931622

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.