ArticleNature chemistry2023
Structural resolution of a small organic molecule by serial X-ray free-electron laser and electron crystallography.
Article in Nature chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Capturing irreversible photoswitching inChemical communications (Cambridge, England) · 2026Article
- A simple and practical approach for protein serial crystallography using grease matrix and large-area support film.Journal of synchrotron radiation · 2026Article
- Practical crystallography with a transmission electron microscope.Journal of microscopy · 2026Article
- Article
- Multi-Crystal X-Ray Diffraction (MCXRD) Bridges the Crystallographic Characterisation Gap in Chemistry and Materials Science: Application to MOFs.Angewandte Chemie (International ed. in English) · 2026Article
- Strategies for mitigating radiation damage and improving data completeness in 3D electron diffraction of protein crystals.Acta crystallographica. Section D, Structural biology · 2026Article
- Serial Chemical Crystallography for Autonomous Quantitative Phase Analysis in an Electron Microscope.Small methods · 2025Article
- Article
- The Impact of X-ray Damage in Chemical Crystalline Materials and New Opportunities for Small Molecule Serial Crystallography.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- Machine learning for the classification of serial electron diffraction patterns: synthetic data.Acta crystallographica. Section A, Foundations and advances · 2025Article
- Preparing submicrometer crystals for electron diffraction.Nature protocols · 2025Article
- Comprehensive microcrystal electron diffraction sample preparation for cryo-EM.Nature protocols · 2025Review
- Thermal deformation compensation scheme to the sub-nanometre level of a piezoelectric offset mirror for MHz repetition rate free-electron laser.Journal of synchrotron radiation · 2025Article
- Convergent-beam attosecond x-ray crystallography.Structural dynamics (Melville, N.Y.) · 2025Article
- Streamlined modular synthesis of saframycin substructure via copper-catalyzed three-component assembly and gold-promoted 6-Beilstein journal of organic chemistry · 2025Article
- Development and commissioning of a broadband online X-ray spectrometer for the SXFEL Facility.Journal of synchrotron radiation · 2024Article
- Real-time observation of a metal complex-driven reaction intermediate using a porous protein crystal and serial femtosecond crystallography.Nature communications · 2024Article
- Reaching the potential of electron diffraction.Cell reports. Physical science · 2024Article
- 3D Nanocrystallography and the Imperfect Molecular Lattice.Annual review of physical chemistry · 2024Review
- Exploration and development of molecule-based printed electronics materials: an integrated approach using experimental, computational, and data sciences.Science and technology of advanced materials · 2024Review
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
Abstract
Structure analysis of small crystals is important in areas ranging from synthetic organic chemistry to pharmaceutical and material sciences, as many compounds do not yield large crystals. Here we present the detailed characterization of the structure of an organic molecule, rhodamine-6G, determined at a resolution of 0.82 Å by an X-ray free-electron laser (XFEL). Direct comparison of this structure with that obtained by electron crystallography from the same sample batch of microcrystals shows that both methods can accurately distinguish the position of some of the hydrogen atoms, depending on the type of chemical bond in which they are involved. Variations in the distances measured by XFEL and electron diffraction reflect the expected differences in X-ray and electron scatterings. The reliability for atomic coordinates was found to be better with XFEL, but the electron beam showed a higher sensitivity to charges.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.