ReviewPaediatric drugs2023
An Update of Pharmacological Management in Children with Functional Constipation.
Review in Paediatric drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- European Society for Paediatric Gastroenterology, Hepatology and Nutrition/North American Society for Pediatric Gastroenterology, Hepatology and Nutrition guidelines for treatment of functional constipation in children aged 0-18 years.Journal of pediatric gastroenterology and nutrition · 2026Guideline
- Efficacy of physiotherapeutic interventions in the management of functional constipation in pediatric and adolescent populations: a systematic review and meta-analysis.European journal of pediatrics · 2026Pooled it
- A post hoc analysis of linaclotide in pediatric patients with functional constipation and neurodevelopmental disorders.Journal of pediatric gastroenterology and nutrition · 2026Trial
- Effect of adding telerehabilitation home program to pharmaceutical treatment on the symptoms and the quality of life in children with functional constipation: a randomized controlled trial.European journal of pediatrics · 2024Trial
- Dysregulation of the HSF1-Mediated UPRBiomolecules · 2026Article
- Refractory/therapy-resistant/intractable constipation in children.BMJ paediatrics open · 2026Article
- Dietary fiber in pediatric gastrointestinal health: a narrative review of evidence and challenges.Clinical and experimental pediatrics · 2026Review
- Drug-related problems in pediatric patients with chronic kidney disease: A single-center prospective study.Experimental and therapeutic medicine · 2026Article
- Clinical Efficacy and Safety of Shenqu Xiaoshi Oral Liquid for Functional Constipation in Children: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2026Review
- Epidemiology of childhood constipation: a national study of Swedish children from 2006 to 2023.BMC pediatrics · 2025Article
- Current Treatment Options for Children with Functional Constipation-What Is in the Pipeline?Children (Basel, Switzerland) · 2025Review
- Microbiota-A Rescuing Modulator in Children Struggling with Functional Constipation.Microorganisms · 2025Review
- Evaluating high dose laxatives via nasogastric tube versus enemas in children with severe constipation: a prospective cohort study.BMC pediatrics · 2025Article
- Tethered cord syndrome (TCS) and constipation in children: a multifaceted approach (literature review).Annals of medicine and surgery (2012) · 2025Review
- Weaning strategies for osmotic laxatives in children with functional constipation: a pilot multicenter randomized controlled trial.Translational pediatrics · 2025Article
- Addressing functional constipation in children: A call for comprehensive and collaborative management.World journal of gastroenterology · 2025Article
- Functional constipation in pediatric patients: an observational study in southern Brazil.Sao Paulo medical journal = Revista paulista de medicina · 2025Observational
- Management of pediatric patients admitted for colonic disimpaction: A scoping review protocol.JPGN reports · 2024Article
- Expert Consensus Document: An Algorithm for the Care and Treatment of Patients with Constipation Based on Ultrasonographic Findings in the Rectum.Diagnostics (Basel, Switzerland) · 2024Article
- Lactitol Alleviates Loperamide-Induced Constipation in Sprague Dawley Rats by Regulating Serotonin, Short-Chain Fatty Acids, and Gut Microbiota.Foods (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional constipation is a common problem in childhood worldwide and has a great impact on social, physical, and emotional functioning of affected children and their caregivers. It is a clinical diagnosis based on the Rome IV criteria. Non-pharmacological treatment involves education, demystification, lifestyle advice, and toilet training. Pharmacological treatment consists of disimpaction, maintenance treatment, and eventually weaning if possible. Polyethylene glycol is considered as the first choice of laxative for both disimpaction and maintenance treatment. Different osmotic laxatives, stimulant laxatives, lubricants, and enemas are available as alternative pharmacological treatment options. Novel drugs are emerging but evidence to support the widespread application of these drugs in the pediatric population is often lacking and more high-quality research is needed in this field. If children remain symptomatic despite optimal pharmacological treatment, botulinum toxin injections in the anal sphincter can be considered as an alternative, more invasive treatment option. This review provides an update on currently available literature concerning the pharmacologic treatment of functional constipation in children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.