Evidence map›Paper›PMID 36941313›Full record

ArticleScientific reports2023

Probing the behavior and kinetic studies of amphiphilic acrylate copolymers with bovine serum albumin.

Shehla Mushtaq, Muhammad Asad Abbas, Habib Nasir, Azhar Mahmood, Mudassir Iqbal, Hussnain A Janjua, Nasir M Ahmad

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Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shehla MushtaqDepartment of Chemistry, School of Natural Sciences (SNS), National University of Sciences and Technology, H-12, Islamabad, 44000, Pakistan.
Muhammad Asad AbbasPolymers Research Lab, Polymers and Composites Research Group, School of Chemical and Materials Engineering (SCME), National University of Sciences and Technology, H-12, Islamabad, 44000, Pakistan.
Habib NasirDepartment of Chemistry, School of Natural Sciences (SNS), National University of Sciences and Technology, H-12, Islamabad, 44000, Pakistan.
Azhar MahmoodDepartment of Chemistry, School of Natural Sciences (SNS), National University of Sciences and Technology, H-12, Islamabad, 44000, Pakistan.
Mudassir IqbalDepartment of Chemistry, School of Natural Sciences (SNS), National University of Sciences and Technology, H-12, Islamabad, 44000, Pakistan.
Hussnain A JanjuaDepartment of Industrial Biotechnology, Atta-Ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology, H-12, Islamabad, 44000, Pakistan.
Nasir M AhmadPolymers Research Lab, Polymers and Composites Research Group, School of Chemical and Materials Engineering (SCME), National University of Sciences and Technology, H-12, Islamabad, 44000, Pakistan. nasir.ahmad@scme.nust.edu.pk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article presents that acrylate copolymers are the potential candidate against the adsorption of bovine serum albumin (BSA). A series of copolymers poly(methyl methacrylate) (pMMA), poly(3-sulfopropyl methacrylate-co-methyl methacrylate) p(SPMA-co-MMA), and poly(dimethylaminoethyl methacrylate-co-methyl methacrylate) p(DMAEMA-co-MMA) were synthesized via free radical polymerization. These amphiphilic copolymers are thermally stable with a glass transition temperature (Tg) 50-120 °C and observed the impact of surface charge on amphiphilic copolymers to control interactions with the bovine serum albumin (BSA). These copolymers pMD1 and pMS1 have surface charges, - 56.6 and - 72.6 mV at pH 7.4 in PBS buffer solution that controls the adsorption capacity of bovine serum albumin (BSA) on polymers surface. Atomic force microscopy (AFM) analysis showed minimum roughness of 0.324 nm and 0.474 nm for pMS1 and pMD1. Kinetic studies for BSA adsorption on these amphiphilic copolymers showed the best fitting of the pseudo-first-order model that showed physisorption and attained at 25 °C and pH 7.4 within 24 h.

Indexed as

PolymersSerum Albumin, BovineAcrylatesKineticsMethacrylatesMethylmethacrylatesPolymethyl MethacrylateAcrylatesacrylic aciddimethylaminoethyl methacrylate-methylmethacrylate copolymerMethacrylatesMethylmethacrylatesPolymersPolymethyl MethacrylateSerum Albumin, Bovine

Identifiers

PMID36941313
PMCPMC10027669

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