ArticleNature communications2023
Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus.
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Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Disease modification in lupus nephritis: towards a pathophysiology-based treatment paradigm.Nature reviews. Nephrology · 2026Review
- Discordance between disease activity and long-term outcomes in DNASE1L3 deficiency: a multicentre longitudinal cohort study.Lupus science & medicine · 2026Article
- The SLC15A4-TASL complex is essential for lupus development in mice.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A cholinergic checkpoint controls autoantibody selection via somatic hypermutation in lupus germinal centers.Cellular & molecular immunology · 2026Article
- Germinal-centre and extrafollicular B cell pathways in systemic lupus erythematosus.Nature reviews. Rheumatology · 2026Review
- The emerging clinical relevance of cell-free DNA in lupus: from mechanistic insights to therapeutic opportunities.Frontiers in immunology · 2026Review
- The role of DNASE1L3 in systemic lupus erythematosus: from pathogenesis to clinical implications.Clinical and experimental medicine · 2025Review
- Immunopathogenesis and Therapeutics of Systemic Lupus Erythematosus: an Integrative Review.Clinical reviews in allergy & immunology · 2025Review
- Systematic profiling reveals hepatic immune and metabolic dysregulation in DNASE1L3-deficient mice.iScience · 2025Article
- Article
- Precision targeting of autoreactive B cells in systemic lupus erythematosus using anti-9G4 idiotope synthetic immune receptor T cells.bioRxiv : the preprint server for biology · 2025Article
- Catalytic IgG Antibodies Hydrolyze DNA, Histones, and HMGB1 in Systemic Lupus Erythematosus.International journal of molecular sciences · 2025Article
- Anti-TFAM antibodies link mitochondrial damage with antiphospholipid syndrome and thrombosis in SLE.Annals of the rheumatic diseases · 2025Article
- Unique characteristics of autoantibodies targeting MET in patients with breast and lung cancer.JCI insight · 2025Article
- How (Ultra-)Rare Gene Variants Improve Our Understanding of More Common Autoimmune and Inflammatory Diseases.ACR open rheumatology · 2025Review
- Emerging concepts and treatments in autoinflammatory interferonopathies and monogenic systemic lupus erythematosus.Nature reviews. Rheumatology · 2025Review
- Lupus and other autoimmune diseases: Epidemiology in the population of African ancestry and diagnostic and management challenges in Africa.The journal of allergy and clinical immunology. Global · 2024Review
- The immunology of systemic lupus erythematosus.Nature immunology · 2024Review
- A dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and death in genetic and induced lupus models.JCI insight · 2024Article
- Rethinking antiphospholipid syndrome to guide future management and research.Nature reviews. Rheumatology · 2024Review
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Authors and funding
16 authors at 4 institutions in 2 countries.
Eduardo Gomez-Bañuelos *Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA.ORCID 0000-0001-9730-1851
Yikai Yu *Department of Rheumatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, P. R. China.ORCID 0000-0003-0910-145X
Jessica LiDivision of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA.
Kevin S CashmanDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, 30322, USA.
Merlin PazDivision of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA.
Maria Isabel Trejo-ZambranoDivision of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA.
Regina BugrovskyDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, 30322, USA.
Youliang WangDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, 30322, USA.
Asiya Seema ChidaDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, 30322, USA.
Cheryl A Sherman-BaustGene Regulation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD, 21224, USA.ORCID 0000-0001-7977-4698
Dylan P FerrisDivision of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA.
Daniel W GoldmanDivision of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA.ORCID 0000-0001-5003-3503
Erika DarrahDivision of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA.ORCID 0000-0003-1119-0279
Michelle PetriDivision of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA.ORCID 0000-0003-1441-5373
Iñaki SanzDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, 30322, USA.ORCID 0000-0003-4182-587X
Felipe AndradeDivision of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA. andrade@jhmi.edu.ORCID 0000-0003-3415-0704
Johns Hopkins University · USEmory University · USNational Institute on Aging · USTongji Hospital · CN
Funding
Regulation of B cell Responses in SLE and Other Autoimmune DiseasesU19AI110483 · NIAID · EMORY UNIVERSITY · PI JEREMY M. BOSS · 2014 to 2026
$76.6MRegulation of Pathogenic Plasma Cells in Human SLEP01AI125180 · NIAID · EMORY UNIVERSITY · PI Ignacio E. Sanz · 2016 to 2026
$28.2MA Model System for the Study of Human B-cell ToleranceR37AI049660 · NIAID · UNIVERSITY OF ROCHESTER · PI SANZ, IGNACIO E. · 2010 to 2019
$3.7MHopkins Lupus CohortR01AR069572 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI PETRI, MICHELLE A · 2016 to 2020
$3.4MThe role of complement citrullination in RA pathogenesisR01AR069569 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI ANDRADE, FELIPE · 2016 to 2020
$1.8MAutoimmunity to LINE-1-encoded antigens in SLE pathogenesisR21AI147598 · NIAID · JOHNS HOPKINS UNIVERSITY · PI ANDRADE, FELIPE · 2020 to 2021
$450kTranscription factor A mitochondria in SLE pathogenesisR21AI169851 · NIAID · JOHNS HOPKINS UNIVERSITY · PI ANDRADE, FELIPE · 2022 to 2023
$450kNIAID NIH HHS P01 AI125180NIAID NIH HHS R21 AI147598NIAID NIH HHS R21 AI169851NIAID NIH HHS R37 AI049660NIAID NIH HHS U19 AI110483NIAMS NIH HHS R01 AR069569NIAMS NIH HHS R01 AR069572
Abstract
Anti-dsDNA antibodies are pathogenically heterogeneous, implying distinct origins and antigenic properties. Unexpectedly, during the clinical and molecular characterization of autoantibodies to the endonuclease DNase1L3 in patients with systemic lupus erythematosus (SLE), we identified a subset of neutralizing anti-DNase1L3 antibodies previously catalogued as anti-dsDNA. Based on their variable heavy-chain (V
Indexed as
Lupus Erythematosus, SystemicAntibodies, AntinuclearAntibodies, MonoclonalAutoantibodiesDNAEndodeoxyribonucleasesHumansAntibodies, AntinuclearAntibodies, MonoclonalAutoantibodiesDNADNASE1L3 protein, humanEndodeoxyribonucleases
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