Evidence map›Paper›PMID 36941254›Full record

ArticleNature communications2023

Evolutionary conservation of the fidelity of transcription.

Claire Chung, Bert M Verheijen, Zoe Navapanich, Eric G McGann, Sarah Shemtov, Guan-Ju Lai, Payal Arora, Atif Towheed, Suraiya Haroon, Agnes Holczbauer and 11 more

Open access · goldFull text read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
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  14. Mitochondrial protein synthesis quality control.Human molecular genetics · 2024
    Review
  15. Emerging Roles of Vitamin BInternational journal of molecular sciences · 2024
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 8 institutions in 3 countries.

Claire ChungSchool of Gerontology, University of Southern California, Los Angeles, CA, USA.
Bert M VerheijenSchool of Gerontology, University of Southern California, Los Angeles, CA, USA.
Zoe NavapanichSchool of Gerontology, University of Southern California, Los Angeles, CA, USA.
Eric G McGannSchool of Gerontology, University of Southern California, Los Angeles, CA, USA.
Sarah ShemtovSchool of Gerontology, University of Southern California, Los Angeles, CA, USA.
Guan-Ju LaiSchool of Gerontology, University of Southern California, Los Angeles, CA, USA.
Payal AroraDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
Atif TowheedChildren's hospital of Philadelphia, Center for Mitochondrial and Epigenomic Medicine, Philadelphia, PA, USA.ORCID 0000-0003-4390-7844
Suraiya HaroonChildren's hospital of Philadelphia, Center for Mitochondrial and Epigenomic Medicine, Philadelphia, PA, USA.ORCID 0000-0001-5575-4609
Agnes HolczbauerChildren's hospital of Philadelphia, Center for Mitochondrial and Epigenomic Medicine, Philadelphia, PA, USA.
Sharon ChangKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-6700-4036
Zarko ManojlovicKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0001-9705-4088
Stephen SimpsonCollege of Life Sciences and Agriculture, University of New Hampshire, Durham, NH, USA.
Kelley W ThomasCollege of Life Sciences and Agriculture, University of New Hampshire, Durham, NH, USA.ORCID 0000-0002-0945-5269
Craig KaplanDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-7518-695X
Peter van HasseltDepartment of Metabolic Disease, University of Utrecht, Utrecht, the Netherlands.
Marc TimmersDepartment of Urology, Medical Center - University of Freiburg, Freiburg, Germany.ORCID 0000-0001-7062-1417
Dorothy ErieDepartment of Chemistry, University of North Carolina, Chapel Hill, NC, USA.
Lin ChenDepartment of Molecular and Cellular Biology, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-4798-6199
Jean-Franćois GoutDepartment of Biological Sciences, Mississippi State University, Mississippi State, MS, USA.
Marc VermulstSchool of Gerontology, University of Southern California, Los Angeles, CA, USA. vermulst@usc.edu.ORCID 0000-0003-4909-5496
University of Southern California · USChildren's Hospital of Philadelphia · USUniversity of New Hampshire · USUniversity of Pittsburgh · USMississippi State University · USUniversity of Freiburg · DEUniversity of North Carolina at Chapel Hill · USUtrecht University · NL

Funding

Integrative single molecule studies: DNA repair and technology developmentR35GM127151 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DOROTHY A ERIE · 2018 to 2026
$4.6M
Mechanisms of RNA Polymerase II transcriptionR35GM144116 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Craig Kaplan · 2022 to 2026
$3.4M
Understanding the role of transcription errors in aging and diseaseR01AG054641 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VERMULST, MARC · 2017 to 2021
$1.7M
Quantitative analysis of transient DNA repair processes in vivoR01GM109832 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BRUSTAD, ERIC MICHAEL, ERIE, DOROTHY A · 2014 to 2017
$1.0M
NIA NIH HHS R01 AG054641NIGMS NIH HHS R01 GM109832NIGMS NIH HHS R35 GM127151NIGMS NIH HHS R35 GM144116
6 · The paper itself

Abstract

Accurate transcription is required for the faithful expression of genetic information. However, relatively little is known about the molecular mechanisms that control the fidelity of transcription, or the conservation of these mechanisms across the tree of life. To address these issues, we measured the error rate of transcription in five organisms of increasing complexity and found that the error rate of RNA polymerase II ranges from 2.9 × 10

Indexed as

RNA Polymerase IITranscription, GeneticAnimalsHumansMiceSaccharomyces cerevisiaeRNA Polymerase II

Identifiers

PMID36941254
PMCPMC10027832
OpenAlexW4328048042

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read52
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.