SynthesisEpilepsy & behavior : E&B2023
The relationship between physical activity and cognitive function in people with epilepsy: A systematic review.
Synthesis in Epilepsy & behavior : E&B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Prepare, don't scare: Rethinking cognitive readiness before epilepsy surgery.Epilepsia open · 2026Article
- The role of social context in cognitive and neurobehavioural outcomes in epilepsy.Nature reviews. Neurology · 2026Review
- Epilepsy and exercise: a narrative review on the crucial role of neurosteroids in modulating GABAergic neurotransmission.Brain communications · 2026Review
- Physical activity levels may impact on the risk of premature mortality in people with epilepsy.Nature communications · 2025Article
- Examining the role of physical activity in older adults with epilepsy.Epilepsy & behavior reports · 2025Review
- Causal association of sarcopenia-related traits with brain cortical structure: a bidirectional Mendelian randomization study.Aging clinical and experimental research · 2025Article
- Proceedings of the 2022 "Lifestyle Intervention for Epilepsy (LIFE)" symposium hosted by Cleveland Clinic.Epilepsia open · 2024Article
- Neuromorphometric associations with mood, cognition, and self-reported exercise levels in epilepsy and healthy individuals.Epilepsy & behavior reports · 2024Article
- Aerobic exercise alters DNA hydroxymethylation levels in an experimental rodent model of temporal lobe epilepsy.Epilepsy & behavior reports · 2024Article
- Sex-specific associations of muscular fitness with overall academic performance and specific school subjects in adolescents: the EHDLA study.Frontiers in psychology · 2024Article
- Association of EEG-assessed phase lag index with cognitive dysfunction and seizure occurrence in children with epilepsy.American journal of translational research · 2024Article
- Exercise, memory, and the hippocampus: Uncovering modifiable lifestyle reserve factors in refractory epilepsy.Epilepsy & behavior reports · 2024Article
- Do people with epilepsy want to participate in an exercise intervention randomized controlled trial? - Results of a brief survey and its preliminary application.Epilepsy & behavior reports · 2023Article
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Authors and funding
2 authors.
Funding
Abstract
backgroundThis study aimed to systematically review the published literature evaluating the association between physical activity and cognitive function in people with epilepsy (PWE).
methodsA comprehensive search of PubMed, Cochrane, Embase, and PsychInfo was performed on June 20, 2022. Studies were excluded if they were not available in the English language, contained animal data only, did not include any original data, were not peer-reviewed, or did not include PWE as a discrete group. PRISMA guidelines were followed. The GRADE scale was used to assess the risk of bias.
resultsSix studies were identified with a total of 123 participants. These included one observational study and five interventional studies, only one of which was a randomized controlled trial. In all studies, there was a positive association between physical activity and cognitive function in PWE. Both interventional studies showed improvement in at least one domain of cognitive functioning, though there was heterogeneity in the outcome measures used.
conclusionsThere is a potential positive association between physical activity and cognitive function in PWE, but available data is limited by heterogeneity, small sample size, and an overall lack of published studies in this area of research. There is a need for more robust studies to be performed in larger samples of PWE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.