ArticleAnnals of internal medicine2023
Assessing Heterogeneity of Treatment Effect in Real-World Data.
Article in Annals of internal medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The efficacy and safety of sacituzumab govitecan in the treatment of breast cancer: a systemic review and meta-analysis of emerging clinical data.Frontiers in immunology · 2025Pooled it
- Cognitive benefits of hearing intervention vary by risk of cognitive decline: A secondary analysis of the ACHIEVE trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Progesterone for Neurodevelopment in Fetuses With Congenital Heart Defects: A Randomized Clinical Trial.JAMA network open · 2024Trial
- The evolving landscape of obesity pharmacotherapy.Nature reviews. Drug discovery · 2026Review
- Review
- Article
- Real-world effectiveness of Avelumab maintenance in advanced urothelial carcinoma: results from the Italian multicenter MALVA study (Meet-URO 25).The oncologist · 2025Observational
- Machine learning for predicting cardiovascular events in older adults with type 2 diabetes using Medicare claims and electronic health records.Journal of clinical epidemiology · 2025Article
- Preoperative predictors of chronic pain after laparoendoscopic groin hernia repair: A Swedish Hernia Registry study.Hernia : the journal of hernias and abdominal wall surgery · 2025Article
- Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery.Nature medicine · 2025Article
- Predictive Modeling of Heterogeneous Treatment Effects in RCTs: A Scoping Review.JAMA network open · 2025Article
- Characterizing Treatment Effect Heterogeneity Using Real-World Data.Clinical pharmacology and therapeutics · 2025Review
- Potential clinical impact of predictive modeling of heterogeneous treatment effects: scoping review of the impact of the PATH Statement.medRxiv : the preprint server for health sciences · 2025Article
- Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery: a multi-ancestry study in 10 960 individuals from 9 biobanks.medRxiv : the preprint server for health sciences · 2025Article
- Toward Precision in Critical Care Research: Methods for Observational and Interventional Studies.Critical care medicine · 2024Review
- Computational simulation of the potential improvement in clinical outcomes of cardiovascular diseases with the use of a personalized predictive medicine approach.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- Real-world evidence to support regulatory submissions: A landscape review and assessment of use cases.Clinical and translational science · 2024Review
- Article
- Clinical data mining: challenges, opportunities, and recommendations for translational applications.Journal of translational medicine · 2024Review
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
Abstract
Increasing availability of real-world data (RWD) generated from patient care enables the generation of evidence to inform clinical decisions for subpopulations of patients and perhaps even individuals. There is growing opportunity to identify important heterogeneity of treatment effects (HTE) in these subgroups
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.