Evidence map›Paper›PMID 36940342›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

WDFY4 deficiency in NOD mice ameliorates autoimmune diabetes and insulitis.

Stephen T Ferris, Tiantian Liu, Jing Chen, Ray A Ohara, Feiya Ou, Renee Wu, Sunkyung Kim, Theresa L Murphy, Kenneth M Murphy

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. CD20Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Advancing Animal Models of Human Type 1 Diabetes.Cold Spring Harbor perspectives in medicine · 2024
    Review
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Stephen T FerrisDepartment of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.
Tiantian LiuDepartment of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.ORCID 0000-0001-9377-9938
Jing ChenDepartment of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.
Ray A OharaDepartment of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.
Feiya OuDepartment of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.
Renee WuDepartment of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.
Sunkyung KimDepartment of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.
Theresa L MurphyDepartment of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.
Kenneth M MurphyDepartment of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.
Cincinnati Children's Hospital Medical Center · US

Funding

Molecular Basis of cDC1 DevelopmentR01AI162643 · NIAID · WASHINGTON UNIVERSITY · PI MURPHY, KENNETH M · 2022 to 2025
$2.8M
Function of Wdfy4 in cross-presentation and immunityR01AI150297 · NIAID · WASHINGTON UNIVERSITY · PI MURPHY, KENNETH M · 2019 to 2023
$2.5M
Understanding the Mechanisms of DC Licensing in CD8 T Cell PrimingR01CA248919 · NCI · WASHINGTON UNIVERSITY · PI MURPHY, KENNETH M · 2021 to 2025
$2.3M
Mechanism of c-MYC repression by IRF8 in myeloid lineagesR21AI164142 · NIAID · WASHINGTON UNIVERSITY · PI MURPHY, KENNETH M · 2021 to 2022
$433k
The role of EMT transcription factor Zeb2 in fetal hematopoiesisF30HL167565 · NHLBI · WASHINGTON UNIVERSITY · PI CHEN, JING · 2023 to 2025
$142k
The role of type 1 dendritic cells in CD4 and CD8 T cell anti-tumor immunityF30CA247262 · NCI · WASHINGTON UNIVERSITY · PI WU, RENEE PAULA · 2021 to 2023
$117k
NCI NIH HHS F30 CA247262NCI NIH HHS R01 CA248919NHLBI NIH HHS F30 HL167565NIAID NIH HHS R01 AI150297NIAID NIH HHS R01 AI162643NIAID NIH HHS R21 AI164142
6 · The paper itself

Abstract

The events that initiate autoimmune diabetes in nonobese diabetic (NOD) mice remain poorly understood. CD4

Indexed as

Diabetes Mellitus, Type 1Islets of LangerhansAnimalsCD8-Positive T-LymphocytesHistocompatibility Antigens Class IIMiceMice, Inbred C57BLMice, Inbred NODHistocompatibility Antigens Class IIcDC1cross-presentationnon obese diabetestype 1 diabetesWDFY4

Identifiers

PMID36940342
PMCPMC10068798
OpenAlexW4327909392

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.