Evidence map›Paper›PMID 36940238›Full record

ArticleThe Journal of asthma : official journal of the Association for the Care of Asthma2023

Investigations of a combination of atopic status and age of asthma onset identify asthma subphenotypes.

Huashi Li, Mario Castro, Loren C Denlinger, Serpil C Erzurum, John V Fahy, Benjamin Gaston, Elliot Israel, Nizar N Jarjour, Bruce D Levy, David T Mauger and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of asthma : official journal of the Association for the Care of Asthma, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Racial differences in odds of asthma exacerbations among Aspergillus fumigatus-sensitized adults with asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 10 institutions in 1 country.

Huashi LiDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA.
Mario CastroDivision of Pulmonary, Critical Care and Sleep Medicine, University of Kansas School of Medicine, Kansas City, KS, USA.
Loren C DenlingerDepartment of Medicine, University of Wisconsin School of Medicine & Public Health, Madison, WI, USA.
Serpil C ErzurumLerner Research Institute and the Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.
John V FahyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of California at San Francisco, San Francisco, CA, USA.
Benjamin GastonWells Center for Pediatric Research and Riley Hospital for Children, Indiana University, Indianapolis, IN, USA.
Elliot IsraelDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Nizar N JarjourDepartment of Medicine, University of Wisconsin School of Medicine & Public Health, Madison, WI, USA.
Bruce D LevyDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-9515-5731
David T MaugerDepartment of Public Health Sciences, College of Medicine, Penn State University, Hershey, PA, USA.
Wendy C MooreDepartment of Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Sally E WenzelDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA.
Joe ZeinLerner Research Institute and the Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.
Eugene R BleeckerDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA.
Deborah A MeyersDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA.
Yin ChenDepartment of Pharmacology and Toxicology, School of Pharmacy, University of Arizona, Tucson, AZ, USA.
Xingnan LiDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA.ORCID 0000-0002-1208-8658
NHLBI Severe Asthma Research Program (SARP)
University of Arizona · USBrigham and Women's Hospital · USCleveland Clinic Lerner College of Medicine · USUniversity of Wisconsin–Madison · USPennsylvania State University · USRiley Hospital for Children · USUniversity of California, San Francisco · USUniversity of Kansas · USUniversity of Pittsburgh · USWake Forest University · US

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Washington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$45.4M
WORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KOCH, KENNETH L · 1992 to 2010
$35.2M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
ZOSUQUIDAR TRIHYDROCHLORIDE IN NEWLY DIAGNOSED AMLM01RR003186 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI SONDEL, PAUL M · 1986 to 2007
$19.3M
Rapid saliva antigen test for SARS-CoV-2 detectionU01HL146002 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ARONICA, MARK A, CASTRO, MARIO · 2019 to 2023
$17.3M
S-nitrosylation signaling in asthmaP01HL158507 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI LAHM, TIM · 2021 to 2025
$12.0M
VIRALLY-INDUCED STAT-1, STAT-3 AND STAT-6M01RR018390 · NCRR · CLEVELAND CLINIC LERNER COM-CWRU · PI GILDEA, THOMAS · 2003 to 2007
$11.0M
NCATS NIH HHS UL1 TR000427NCATS NIH HHS UL1 TR001102NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR002345NCATS NIH HHS UL1 TR002373NCATS NIH HHS UL1 TR002378NCRR NIH HHS M01 RR003186NCRR NIH HHS M01 RR007122NCRR NIH HHS M01 RR018390NCRR NIH HHS UL1 RR024992NHLBI NIH HHS K08 HL133381NHLBI NIH HHS P01 HL158507NHLBI NIH HHS R01 HL069116NHLBI NIH HHS R01 HL069130NHLBI NIH HHS R01 HL069149NHLBI NIH HHS R01 HL069155NHLBI NIH HHS R01 HL069167NHLBI NIH HHS R01 HL069170NHLBI NIH HHS R01 HL069174NHLBI NIH HHS R01 HL069349NHLBI NIH HHS R01 HL087665NHLBI NIH HHS R01 HL091762NHLBI NIH HHS R01 HL142769NHLBI NIH HHS RC2 HL101487NHLBI NIH HHS U01 HL146002NHLBI NIH HHS U10 HL109086NHLBI NIH HHS U10 HL109146NHLBI NIH HHS U10 HL109152NHLBI NIH HHS U10 HL109164NHLBI NIH HHS U10 HL109168NHLBI NIH HHS U10 HL109172NHLBI NIH HHS U10 HL109250NHLBI NIH HHS U10 HL109257NIAID NIH HHS R01 AI149754
6 · The paper itself

Abstract

objectiveSubphenotypes of asthma may be determined by age onset and atopic status. We sought to characterize early or late onset atopic asthma with fungal or non-fungal sensitization (AAFS or AANFS) and non-atopic asthma (NAA) in children and adults in the Severe Asthma Research Program (SARP). SARP is an ongoing project involving well-phenotyped patients with mild to severe asthma.

methodsPhenotypic comparisons were performed using Kruskal-Wallis or chi-square test. Genetic association analyses were performed using logistic or linear regression.

resultsAirway hyper-responsiveness, total serum IgE levels, and T2 biomarkers showed an increasing trend from NAA to AANFS and then to AAFS. Children and adults with early onset asthma had greater % of AAFS than adults with late onset asthma (46% and 40% vs. 32%;

conclusionsEarly or late onset AAFS, AANFS, and NAA have shared and distinct phenotypic characteristics in children and adults. AAFS is a complex disorder involving genetic susceptibility and environmental factors.

Indexed as

AsthmaHypersensitivity, ImmediateAdultBiomarkersChildHumansLongitudinal StudiesRespiratory Function TestsBiomarkersAge of asthma onsetasthma subphenotypesatopic asthma with fungal sensitizationGSDMBnon-atopic asthmasevere asthma

Identifiers

PMID36940238
PMCPMC10528448
OpenAlexW4327899963

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.