Observational studyEuropean journal of physical and rehabilitation medicine2023
Prefrontal hemodynamics during forward and backward walking, with and without a cognitive task, in people with multiple sclerosis.
Observational study in European journal of physical and rehabilitation medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- The relationship between motor and cognitive performance and cortical activity in patients with multiple sclerosis: a systematic review of functional near-infrared spectroscopy studies.Frontiers in rehabilitation sciences · 2026Pooled it
- The association between cognitive function and physical performance in established users of a lower limb prosthesis.Irish journal of medical science · 2025Article
- Neural correlates of forward and backward walking in MS: insights from myelin water imaging.Experimental brain research · 2025Article
- Real-time cortical activity during virtual reality practice in people with multiple sclerosis: a pilot fNIRS study.Journal of neuroengineering and rehabilitation · 2025Article
- Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHemodynamics in the prefrontal cortex (PFC) while walking forward and backward, with and without an additional cognitive task (motor single-task [ST] and motor cognitive dual-task [DT]) have not been studied in people with multiple sclerosis (pwMS).
aimTo investigate the PFC hemodynamics during forward and as well as backward walking, with and without a cognitive task, in pwMS and healthy controls.
designObservational case-control study.
settingSheba Multiple Sclerosis Center, Tel-Hashomer, Israel. POPULATION: Eighteen pwMS (36.1±11.7 years, 66.6% female) and 17 healthy controls (37.5±13.8 years, 76.5% female).
methodsEach subject completed four walking trials: ST forward walking, DT forward walking, ST backward walking, DT backward walking. PFC activity for all trials was recorded using functional near-infrared spectroscopy (fNIRS). The PFC was subdivided in the frontal eye field (FEF), frontopolar cortex (FPC) and the dorsolateral PFC (DLPFC).
resultsThe relative oxygenated hemoglobin (HbO) concentration was higher during the DT forward walking in all PFC subareas compared with the ST forward walking for both groups. The relative HbO concentration was higher during ST backward walking compared with ST forward walking in pwMS (DLPFC, FEF) and the healthy controls (FEF, FPC), specifically during the initial part of the trial.
conclusionsST backward walking and DT forward walking impact the hemodynamics at the PFC, although, the difference between pwMS and healthy adults requires further clarification. Future RCT's are encouraged to examine the impact of an intervention program based on DT forward and backward walking on PFC activity in pwMS. CLINICAL REHABILITATION IMPACT: Backward walking increases activity in the PFC region in pwMS. Similarly, when performing a cognitive task while walking forward.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.