Evidence map›Paper›PMID 36940015›Full record

SynthesisSleep & breathing = Schlaf & Atmung2023

Meta-analysis of the effects of CPAP therapy on estimated glomerular filtration rate in patients with obstructive sleep apnea.

Yuyu Fu, Jiayu Lin, Lijun Chen, Xiaoyu Chen, Qingshi Chen

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Sleep & breathing = Schlaf & Atmung, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Sleep-Related Disorders in Patients with CKD and Kidney Transplant Recipients.Clinical journal of the American Society of Nephrology : CJASN · 2025
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuyu Fu *Department of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, No.950 Donghai Street, Quanzhou, 362000, Fengze District, China.
Jiayu Lin *Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Fujian Medical University, No. 950 Donghai Street, Quanzhou, 362000, Fengze District, China.
Lijun ChenDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Fujian Medical University, No. 950 Donghai Street, Quanzhou, 362000, Fengze District, China.
Xiaoyu ChenDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Fujian Medical University, No. 950 Donghai Street, Quanzhou, 362000, Fengze District, China. chenxiaoyu271@fjmu.edu.cn.
Qingshi ChenDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Fujian Medical University, No. 950 Donghai Street, Quanzhou, 362000, Fengze District, China. chenqingshi1986@126.com.ORCID 0000-0003-2285-9150

Funding

Science and Technology Bureau of Quanzhou 2022C038RScience and Technology Project of Fujian Education Department JAT200136Startup Fund for Scientific Research, Fujian Medical University 2018QH1105the Joint Funds for the innovation of science and Technology, Fujian province 2021Y9027the project of Fujian Provincial Health Commission 2019-ZQN-66Young and middle-aged backbone talents training project of Fujian Provincial Health Commission 2021GGA040
6 · The paper itself

Abstract

purposeObstructive sleep apnea (OSA) is highly prevalent in patients with chronic kidney disease and may lead to a loss of kidney function. However, it remains unclear whether or not continuous positive airway pressure (CPAP) treatment improves the estimated glomerular filtration rate (eGFR) in patients with OSA. This meta-analysis was designed to investigate the effect of CPAP therapy on eGFR in patients with OSA.

methodsWe searched the electronic databases Web of Science, Cochrane Library, PubMed, and Embase through June 1, 2022. Information about patients, CPAP duration, gender distribution, pre- and post-CPAP treatment eGFR, and age of patients were collected for further analysis. We applied the standardized mean difference (SMD) with a 95%confidence interval (CI) to analyze the pooled effects. Both Stata 12.0 software and Review Manager 5.2 software were employed for all statistical analyses.

resultsA sample of 13 studies with 519 patients was included in the meta-analysis. There was no significant change of eGFR levels before and after CPAP usage for patients with OSA (SMD =  - 0.05, 95%CI: - 0.30 to 0.19, Z = 0.43, p = 0.67). However, subgroup analysis revealed that the level of eGFR was obviously decreased after CPAP therapy in patients with OSA and CPAP use duration > 6 months (SMD =  - 0.30, 95% CI =  - 0.49 to - 0.12, z = 3.20, p = 0.001), and elderly patients (> 60 years) (SMD =  - 0.32, 95% CI =  - 0.52 to - 0.11, z = 3.02, p = 0.002).

conclusionsMeta-analysis confirmed that OSA treatment with CPAP has no clinically significant effect on eGFR.

Indexed as

Continuous Positive Airway PressureSleep Apnea, ObstructiveAgedGlomerular Filtration RateHumansPhysical Therapy ModalitiesContinuous positive airway pressureEstimated glomerular filtration rateMeta‑analysisObstructive sleep apnea

Identifiers

PMID36940015

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.