Evidence map›Paper›PMID 36939855›Full record

ArticlePsychopharmacology2023

Consuming oral cannabidiol prior to a standard alcohol dose has minimal effect on breath alcohol level and subjective effects of alcohol.

Hollis C Karoly, Meggan L Drennan, Mark A Prince, Leila Zulic, Gregory Dooley

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06105138 (Exploring the Effects of Acute Cannabidiol Administration on Blood Alcohol Level and Intoxication in Adult Human Subjects), which is not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06105138 nacompletednot on this map

Exploring the Effects of Acute Cannabidiol Administration on Blood Alcohol Level and Intoxication in Adult Human Subjects

TypeinterventionalSponsorColorado State UniversityRan2021 to 2022Enrolled37ConditionsAlcohol Use DisorderArms200mg Cannabidiol oral solution, 30mg Cannabidiol oral solution, Placebo
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Cannabidiol mitigates alcohol dependence and withdrawal with neuroprotective effects in the basolateral amygdala and striatum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hollis C KarolyDepartment of Psychology, Colorado State University, 1876 Campus Delivery, Fort Collins, CO, 80523-1876, USA. hollis.karoly@colostate.edu.ORCID http://orcid.org/0000-0002-1232-1202
Meggan L DrennanDepartment of Psychology, Colorado State University, 1876 Campus Delivery, Fort Collins, CO, 80523-1876, USA.
Mark A PrinceDepartment of Psychology, Colorado State University, 1876 Campus Delivery, Fort Collins, CO, 80523-1876, USA.
Leila ZulicDepartment of Psychology, Colorado State University, 1876 Campus Delivery, Fort Collins, CO, 80523-1876, USA.
Gregory DooleyDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, 80523-1601, USA.
Colorado State University · US

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Exploring the Effects of Cannabinoids on Alcohol Consumption and the Microbiota-Gut-Brain AxisK23AA028238 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI KAROLY, HOLLIS C · 2021 to 2025
$1.1M
NCATS NIH HHS UL1 TR002535NIAAA NIH HHS K23 AA028238NIAAA NIH HHS K23AA028238
6 · The paper itself

Abstract

rationaleCannabidiol (CBD) is found in the cannabis plant and has garnered attention as a potential treatment for alcohol use disorder (AUD). CBD reduces alcohol consumption and other markers of alcohol dependence in rodents, but human research on CBD and alcohol is limited. It is unknown whether CBD reduces drinking in humans, and mechanisms through which CBD could impact behavioral AUD phenotypes are unknown.

objectivesThis study explores effects of oral CBD on breath alcohol level (BrAC), and subjective effects of alcohol in human participants who report heavy drinking.

methodsIn this placebo-controlled, crossover study, participants consumed 30 mg CBD, 200 mg CBD, or placebo CBD before receiving a standardized alcohol dose. Participants were blind to which CBD dose they received at each session and completed sessions in random order. Thirty-six individuals completed at least one session and were included in analyses.

resultsDifferences in outcomes across the three conditions and by sex were explored using multilevel structural equation models. BrAC fell fastest in the placebo condition, followed by 30 mg and 200 mg CBD. Stimulation decreased more slowly in the 200 mg CBD condition than in placebo (b =  - 2.38, BCI [- 4.46, - .03]). Sedation decreased more slowly in the 30 mg CBD condition than in placebo (b =  - 2.41, BCI [- 4.61, - .09]). However, the magnitude of condition differences in BrAC and subjective effects was trivial.

conclusionsCBD has minimal influence on BrAC and subjective effects of alcohol. Further research is needed to test whether CBD impacts alcohol consumption in humans, and if so, what mechanism(s) may explain this effect.

Indexed as

AlcoholismCannabidiolAlcohol DrinkingCross-Over StudiesDouble-Blind MethodEthanolHumansCannabidiolEthanolAlcoholBreath-alcohol concentrationCannabidiol (CBD)SedationStimulationSubjective effects

Identifiers

PMID36939855
PMCPMC10622182
OpenAlexW4327892772

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.