ArticleAngewandte Chemie (International ed. in English)2023
Two-Dimensional Supramolecular Polymerization of DNA Amphiphiles is Driven by Sequence-Dependent DNA-Chromophore Interactions.
Article in Angewandte Chemie (International ed. in English), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- AIEgen-mediated integration of plain DNA and hydrophobic compounds enabling three-in-one nanosystems for carrier-free delivery.Journal of nanobiotechnology · 2026Article
- Plain DNA and cationic aromatics: a platform to simplify carrier-free delivery systems.Journal of nanobiotechnology · 2025Article
- Complex Donuts: Small Variations in DNA Sequence Dictate Pathway Complexity in DNA Nanotoroids.Angewandte Chemie (International ed. in English) · 2025Article
- Heat-activated growth of metastable and length-defined DNA fibers expands traditional polymer assembly.Nature communications · 2024Article
- Self-assembly of cyclic peptide monolayers by hydrophobic supramolecular hinges.Chemical science · 2023Article
- Synthesis of RNA-Amphiphiles via Atom Transfer Radical Polymerization in the Organic Phase.Precision chemistry · 2023Article
Corrections and comments
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Authors and funding
8 authors.
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Abstract
Two-dimensional (2D) assemblies of water-soluble block copolymers have been limited by a dearth of systematic studies that relate polymer structure to pathway mechanism and supramolecular morphology. Here, we employ sequence-defined triblock DNA amphiphiles for the supramolecular polymerization of free-standing DNA nanosheets in water. Our systematic modulation of amphiphile sequence shows the alkyl chain core forming a cell membrane-like structure and the distal π-stacking chromophore block folding back to interact with the hydrophilic DNA block on the nanosheet surface. This interaction is crucial to sheet formation, marked by a chiral "signature", and sensitive to DNA sequence, where nanosheets form with a mixed sequence, but not with a homogeneous poly(thymine) sequence. This work opens the possibility of forming well-ordered, bilayer-like assemblies using a single DNA amphiphile for applications in cell sensing, nucleic acid therapeutic delivery and enzyme arrays.
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