Evidence map›Paper›PMID 36939433›Full record

Observational studyOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2023

Association of Central Auditory Processing Dysfunction With Preclinical Alzheimer's Disease.

Min Soo Byun, Munyoung Chang, Dahyun Yi, Hyejin Ahn, Dongkyun Han, Seulki Jeon, Hyunsook Jang, Dong Young Lee, Seung Ha Oh, KBASE Research Group

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Min Soo ByunDepartment of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea.ORCID 0000-0003-3159-4510
Munyoung ChangDepartment of Otolaryngology-Head and Neck Surgery, Chung-Ang University College of Medicine, Seoul, South Korea.ORCID 0000-0003-0136-3893
Dahyun YiInstitute of Human Behavioral Medicine, Medical Research Centre, Seoul National University, Seoul, South Korea.ORCID 0000-0002-0860-0946
Hyejin AhnInterdisciplinary Program of Cognitive Science, Seoul National University College of Humanities, Seoul, South Korea.
Dongkyun HanDepartment of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea.
Seulki JeonDepartment of Otolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, South Korea.
Hyunsook JangDivision of Speech Pathology and Audiology, Research Institute of Audiology & Speech Pathology, Hallym University, Chuncheon-si, Gangwon-do, South Korea.
Dong Young LeeDepartment of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea.
Seung Ha OhDepartment of Otolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, South Korea.
KBASE Research Group
Seoul National University · KRChung-Ang University Hospital · KRHallym University · KRSeoul National University Hospital · KR

Funding

KBASE2: Korean Brain Aging Study, Longitudinal Endophenotypes and Systems BiologyU01AG072177 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI LEE, DONG YOUNG, NHO, KWANGSIK TIMOTHY · 2021 to 2025
$11.2M
NIA NIH HHS U01 AG072177
6 · The paper itself

Abstract

objectiveTo investigate whether central auditory processing dysfunction measured by the dichotic digit test-1 digit (DDT1) is present in preclinical Alzheimer's disease (AD) individuals who are cognitively normal (CN) older adults with the cerebral beta-amyloid (Aβ) deposition and to explore the potential of the DDT1 as a screening test for preclinical AD. STUDY

designCross-sectional design.

settingA prospective observational cohort study.

methodsCN older adults with a global clinical dementia rating score of 0 were included. The hearing test battery including pure-tone audiometry, speech audiometry, distortion product otoacoustic emission, and DDT1 was administered to participants.

resultsFifty CN older adults were included. Among them, 38 individuals were included in the Aβ deposition negative (AN) group and 12 were included in the Aβ deposition positive (AP) group. The DDT1 scores of both the better and worse ears were significantly lower in the AP group than in the AN group (p = .008 and p = .015, respectively). No significant differences were observed between the groups in tests of the peripheral auditory pathways. In multivariable logistic regression analysis adjusted for apolipoprotein E4 positivity, the DDT1 better ear score predicted the AP group (p = .036, odds ratio = 0.892, 95% confidence interval: 0.780-0.985) with relatively high diagnostic accuracy.

conclusionOur findings suggest that Aβ deposition may affect the central auditory pathway even before cognitive decline appears. DDT1, which can easily be applied to the old-age population, may have the potential as a screening tool for preclinical AD.

Indexed as

Alzheimer DiseaseCognitive DysfunctionAgedAuditory PerceptionCross-Sectional StudiesHumansPositron-Emission TomographyProspective StudiesAlzheimer's diseaseamyloidcentral auditory processing dysfunctiondichotic digit test

Identifiers

PMID36939433
PMCPMC10846842
OpenAlexW4319789241

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.