ArticleInfection and immunity2023
SarS Is a Repressor of Staphylococcus aureus Bicomponent Pore-Forming Leukocidins.
Article in Infection and immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
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- Special Collection on the 28th Annual Midwest Microbial Pathogenesis Conference.Infection and immunity · 2024Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Staphylococcus aureus is a successful pathogen that produces a wide range of virulence factors that it uses to subvert and suppress the immune system. These include the bicomponent pore-forming leukocidins. How the expression of these toxins is regulated is not completely understood. Here, we describe a screen to identify transcription factors involved in the regulation of leukocidins. The most prominent discovery from this screen is that SarS, a known transcription factor which had previously been described as a repressor of alpha-toxin expression, was found to be a potent repressor of leukocidins LukED and LukSF-PV. We found that inactivating
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