Evidence map›Paper›PMID 36939320›Full record

ArticleeLife2023

Context-dependent requirement of G protein coupling for Latrophilin-2 in target selection of hippocampal axons.

Daniel T Pederick, Nicole A Perry-Hauser, Huyan Meng, Zhigang He, Jonathan A Javitch, Liqun Luo

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 26 citations in OpenAlex.

  1. Altered striatal dopamine regulation in Adgrl3 knockout mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Adhesion G protein-coupled receptors.Pharmacological reviews · 2026
    Review
  6. EndothelialThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. The adhesion GPCR ADGRL2 engages Gα13 to enable epidermal differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Cell Adhesion Molecule Signaling at the Synapse: Beyond the Scaffold.Cold Spring Harbor perspectives in biology · 2024
    Review
  18. Article
  19. Synaptic promiscuity in brain development.Current biology : CB · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Daniel T Pederick *Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, United States.ORCID 0000-0003-1870-9475
Nicole A Perry-Hauser *Departments of Psychiatry and Molecular Pharmacology and Therapeutics, Columbia University Vagelos College of Physicians and Surgeons, New York, United States.ORCID 0000-0003-3130-3023
Huyan MengF.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, United States.ORCID 0000-0003-1511-6156
Zhigang HeF.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, United States.
Jonathan A JavitchDepartments of Psychiatry and Molecular Pharmacology and Therapeutics, Columbia University Vagelos College of Physicians and Surgeons, New York, United States.ORCID 0000-0001-7395-2967
Liqun LuoDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, United States.ORCID 0000-0001-5467-9264
Boston Children's Hospital · USHoward Hughes Medical Institute · USNew York Psychoanalytic Society and Institute · US

Funding

Viral ModuleP30EY012196 · NEI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MARGARET S LIVINGSTONE · 1998 to 2026
$21.3M
Structure of the Dopamine D2-Like Receptor Binding SitesR01MH054137 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI JAVITCH, JONATHAN A · 1995 to 2025
$12.0M
Research Training in Mood and Anxiety Disorders: From Animal Models to PatientsT32MH015144 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Eduardo David Leonardo · 1985 to 2026
$11.1M
Mosaic Analysis with Double Markers in MiceR01NS050835 · NINDS · STANFORD UNIVERSITY · PI LIQUN LUO · 2005 to 2026
$7.3M
NEI NIH HHS P30 EY012196NIMH NIH HHS R01 MH054137NIMH NIH HHS T32 MH015144NINDS NIH HHS R01 NS050835
6 · The paper itself

Abstract

The formation of neural circuits requires extensive interactions of cell-surface proteins to guide axons to their correct target neurons.

Indexed as

AxonsHippocampusGTP-Binding ProteinsLigandsReceptors, Peptidealpha-latrotoxin receptorGTP-Binding ProteinsLigandsReceptors, Peptidedevelopmental biologyG protein signalinglatrophilinmouseneuronal circuit assemblyneuroscience

Identifiers

PMID36939320
PMCPMC10118387
OpenAlexW4327900067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.