Evidence map›Paper›PMID 36938956›Full record

ArticleThe FEBS journal2023

KIAA0317 regulates SOCS1 stability to ameliorate colonic inflammation.

Karina C Lockwood, Travis B Lear, Shristi Rajbhandari, Alison C McKelvey, Sarah R Dunn, Áine N Boudreau, Yuan Liu, Bill B Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The FEBS journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Karina C LockwoodAging Institute, University of Pittsburgh/UPMC, PA, USA.
Travis B LearAging Institute, University of Pittsburgh/UPMC, PA, USA.ORCID 0000-0001-9156-0844
Shristi RajbhandariDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, PA, USA.
Alison C McKelveyDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, PA, USA.
Sarah R DunnDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, PA, USA.
Áine N BoudreauAging Institute, University of Pittsburgh/UPMC, PA, USA.
Yuan LiuAging Institute, University of Pittsburgh/UPMC, PA, USA.
Bill B ChenAging Institute, University of Pittsburgh/UPMC, PA, USA.ORCID 0000-0003-2695-5107

Funding

Systematic Investigation of Protein Ubiquitination in ARDSR35HL139860 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, BEIBEI · 2018 to 2024
$6.3M
Translational Pulmonary Vascular BiologyT32HL110849 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sruti Shiva · 2012 to 2026
$5.0M
DCAF7/HDAC4/TFEB axis in acute lung injuryR01HL142777 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LIU, YUAN · 2018 to 2022
$2.4M
Role of F-Box Proteins in Lung TransplantationR01HL133184 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, BEIBEI, MCDYER, JOHN F · 2017 to 2020
$2.1M
Modulating Alzheimer’s Disease by mTORC1 inhibition to augment lysosomal activityK99AG078342 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEAR, TRAVIS BRADLEY · 2022 to 2023
$245k
NHLBI NIH HHS K99 AG078342NHLBI NIH HHS R01 HL133184NHLBI NIH HHS R01 HL142777NHLBI NIH HHS R35 HL139860NHLBI NIH HHS T32 HL110849NIA NIH HHS K99 AG078342
6 · The paper itself

Abstract

Dysregulated cytokine signalling is a hallmark of inflammatory bowel diseases. Inflammatory responses of the colon are regulated by the suppressor of cytokine signalling (SOCS) proteins. SOCS1 is a key member of this family, and its function is critical in maintaining an appropriate inflammatory response through the JAK/STAT signalling pathway. Dysregulation of SOCS1 protein has been identified as a causal element in colonic inflammatory diseases. Despite this, it remains unclear how SOCS1 protein is regulated. Here, we identify that SOCS1 protein is targeted for degradation by the ubiquitin proteasome system, mediated by the E3 ubiquitin ligase KIAA0317 during experimental colonic inflammation. We characterize the mechanism of protein-protein interaction and ubiquitin conjugation to SOCS1 and demonstrate that the modulation of SOCS1 protein level leads to stark effects on JAK/STAT inflammatory signalling. Together, these results provide insight into the regulation of colonic inflammation through a new mechanism of ubiquitin-based control of SOCS1 protein.

Indexed as

Suppressor of Cytokine Signaling ProteinsUbiquitinColonCytokinesHumansInflammationSuppressor of Cytokine Signaling 1 ProteinCytokinesSOCS1 protein, humanSuppressor of Cytokine Signaling 1 ProteinSuppressor of Cytokine Signaling ProteinsUbiquitinE3 ubiquitin ligaseinflammatory bowel diseaseprotein ubiquitinationsignal transducers and activators of transcription 1suppressor of cytokine signalling 1

Identifiers

PMID36938956
PMCPMC10509311

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.