Evidence map›Paper›PMID 36938756›Full record

Trial reportCirculation2023

Effectiveness of the

Daniel D Kinnamon, Elizabeth Jordan, Garrie J Haas, Mark Hofmeyer, Evan Kransdorf, Gregory A Ewald, Alanna A Morris, Anjali Owens, Brian Lowes, Douglas Stoller and 24 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled TrialMulticenter Study
In one paragraph

Trial report in Circulation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03037632 (Precision Medicine for Dilated Cardiomyopathy in European and African Ancestry), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03037632 naactive not recruitingnot on this map

Precision Medicine for Dilated Cardiomyopathy in European and African Ancestry

TypeinterventionalSponsorRay HershbergerRan2016 to 2026Enrolled6,500ConditionsIdiopathic Dilated CardiomyopathyArmsFamily Heart Talk Booklet
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. The DCM Project Portal: A direct-to-participant platform of The DCM Research Project.American heart journal plus : cardiology research and practice · 2024
    Article
  8. The DCM Project Portal: A direct-to-participant platform of The DCM Research Project.medRxiv : the preprint server for health sciences · 2023
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 20 institutions in 1 country.

Daniel D Kinnamon *Department of Internal Medicine, Division of Human Genetics (D.D.K., E.J., J.O.M., H.N., R.E.H.), The Ohio State University, Columbus.ORCID 0000-0002-0867-5227
Elizabeth Jordan *Department of Internal Medicine, Division of Human Genetics (D.D.K., E.J., J.O.M., H.N., R.E.H.), The Ohio State University, Columbus.ORCID 0000-0002-2073-3258
Garrie J Haasthe Davis Heart and Lung Research Institute (D.D.K., E.J., G.J.H., J.O.M., H.N., R.E.H.), The Ohio State University, Columbus.
Mark HofmeyerMedstar Research Institute, Washington Hospital Center, DC (M.H.).
Evan KransdorfSmidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (E.K.).ORCID 0000-0002-0507-2412
Gregory A EwaldWashington University, St. Louis, MO (G.A.E.).
Alanna A MorrisEmory University School of Medicine, Atlanta, GA (A.A.M.).ORCID 0000-0002-8033-3707
Anjali OwensCenter for Inherited Cardiovascular Disease, Division of Cardiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia (A.O.).ORCID 0000-0002-9669-8495
Brian LowesUniversity of Nebraska Medical Center, Omaha (B.L., D.S.).ORCID 0000-0002-5919-2540
Douglas StollerUniversity of Nebraska Medical Center, Omaha (B.L., D.S.).
W H Wilson TangDepartment of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, OH (W.H.W.T.).ORCID 0000-0002-8335-735X
Sonia GargUniversity of Texas Southwestern Medical Center, Dallas (S.G.).
Barry H TrachtenbergHouston Methodist DeBakey Heart and Vascular Center, J.C. Walter Jr. Transplant Center, TX (B.H.T.).
Palak ShahInova Heart and Vascular Institute, Falls Church, VA (P.S.).ORCID 0000-0001-8175-168X
Salpy V PamboukianUniversity of Alabama, Birmingham (S.V.P.).
Nancy K SweitzerNow with University of Washington, Seattle. Sarver Heart Center, University of Arizona, Tucson (N.K.S.).ORCID 0000-0002-8117-6678
Matthew T WheelerNow with Division of Cardiology, Washington University, St. Louis, MO. Division of Cardiovascular Medicine, Stanford University School of Medicine, CA (M.T.W.).ORCID 0000-0001-8721-3022
Jane E WilcoxNorthwestern University Feinberg School of Medicine, Chicago, IL (J.E.W.).
Stuart KatzNew York University Langone Medical Center, NY (S.K.).ORCID 0000-0003-2340-2021
Stephen PanDepartment of Cardiology, Westchester Medical Center & New York Medical College, Valhalla, NY (S.P.).ORCID 0000-0002-1189-4199
Javier JimenezMiami Cardiac & Vascular Institute, Baptist Health South, FL (J.J.).
Keith D AaronsonUniversity of Michigan Medical Center, Ann Arbor (K.D.A.).ORCID 0000-0003-1538-576X
Daniel P FishbeinUniversity of Washington, Seattle (D.P.F.).
Frank SmartLouisiana State University Health Sciences Center, New Orleans (F.S.).
Jessica WangUniversity of California, Los Angeles Medical Center (J.W.).ORCID 0000-0001-7348-0509
Stephen S GottliebUniversity of Maryland School of Medicine, Baltimore (S.S.G.).ORCID 0000-0002-8922-1840
Daniel P JudgeMedical University of South Carolina, Charleston (D.P.J.).ORCID 0000-0002-3407-0248
Charles K MooreUniversity of Mississippi Medical Center, Jackson (C.K.M.).
Jonathan O MeadDepartment of Internal Medicine, Division of Human Genetics (D.D.K., E.J., J.O.M., H.N., R.E.H.), The Ohio State University, Columbus.
Gordon S HugginsCardiology Division, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.).
Hanyu NiDepartment of Internal Medicine, Division of Human Genetics (D.D.K., E.J., J.O.M., H.N., R.E.H.), The Ohio State University, Columbus.ORCID 0000-0002-0175-5718
Wylie BurkeDepartment of Bioethics and Humanities, University of Washington, Seattle (W.B.).ORCID 0000-0003-2914-0560
Ray E HershbergerDepartment of Internal Medicine, Division of Human Genetics (D.D.K., E.J., J.O.M., H.N., R.E.H.), The Ohio State University, Columbus.ORCID 0000-0001-5683-6526
DCM Precision Medicine Study of the DCM Consortium
Lung Institute · USUniversity of Nebraska Medical Center · USUniversity of Washington · USWashington University in St. Louis · USAlaska Heart and Vascular Institute · USBaptist Hospital of Miami · USCedars-Sinai Smidt Heart Institute · USCleveland Clinic · USEmory University · USHouston Methodist · USLos Angeles Medical Center · USLouisiana State University Health Sciences Center New Orleans · USMedical University of South Carolina · USMedStar Washington Hospital Center · USNorthwestern University · USNYU Langone Health · USThe University of Texas Southwestern Medical Center · USTufts University · USUniversity of Alabama at Birmingham · USUniversity of Arizona · US

Funding

Precision Medicine for Dilated Cardiomyopathy in European and African AncestryR01HL128857 · NHLBI · OHIO STATE UNIVERSITY · PI HERSHBERGER, RAY E. · 2015 to 2020
$12.4M
Functional Validation of Myh14 in Stress-Induced Cardiac Remodeling.K08HL133491 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WANG, JESSICA J · 2017 to 2021
$875k
NHLBI NIH HHS K08 HL133491NHLBI NIH HHS R01 HL128857
6 · The paper itself

Abstract

backgroundManaging disease risk among first-degree relatives of probands diagnosed with a heritable disease is central to precision medicine. A critical component is often clinical screening, which is particularly important for conditions like dilated cardiomyopathy (DCM) that remain asymptomatic until severe disease develops. Nonetheless, probands are frequently ill-equipped to disseminate genetic risk information that motivates at-risk relatives to complete recommended clinical screening. An easily implemented remedy for this key issue has been elusive.

methodsThe DCM Precision Medicine Study developed

resultsBetween June 2016 and March 2020, 1241 probands were randomized (1:1) to receive

conclusionsREGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT03037632.

Indexed as

Cardiomyopathy, DilatedEthnicityFamilyFamily HealthHumansRisk Assessmentcardiomyopathydilatedhealth communicationrandomized controlled trial

Identifiers

PMID36938756
PMCPMC10133091
OpenAlexW4327893309

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.