Evidence map›Paper›PMID 36938496›Full record

ArticleNature cardiovascular research2022

YES to Junctions, No to Src.

Michael Simons, Derek Toomre

Abstract read
In one paragraph

Article in Nature cardiovascular research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Michael SimonsYale Cardiovascular Research Center and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06511.
Derek ToomreYale Cardiovascular Research Center and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06511.

Funding

Surgery / Physiology CoreP01HL107205 · NHLBI · YALE UNIVERSITY · PI SIMONS, MICHAEL · 2012 to 2022
$18.8M
SYNDECAN FUNCTION IN ENDOTHELIAL CELLSR01HL062289 · NHLBI · YALE UNIVERSITY · PI SIMONS, MICHAEL · 1999 to 2021
$9.6M
Dynamic control of vascular permeability in development and diseaseR01HL149343 · NHLBI · YALE UNIVERSITY · PI EICHMANN, ANNE CHRISTINE, SIMONS, MICHAEL · 2019 to 2022
$3.3M
NHLBI NIH HHS P01 HL107205NHLBI NIH HHS R01 HL062289NHLBI NIH HHS R01 HL149343
6 · The paper itself

Abstract

Regulation of the endothelial barrier function is critical to physiological function of the vasculature, which must dynamically change in a number of physiologic and pathologic settings. A new study emphasizes the complex relationship between VE-cadherin phosphorylation , the critical role of YES in this process, and the vascular leak.

Identifiers

PMID36938496
PMCPMC10021110

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.