Evidence map›Paper›PMID 36938380›Full record

ArticleMindfulness2022

Biomarker Response to Mindfulness Intervention in Veterans Diagnosed with Post-traumatic Stress Disorder.

Itamar Shapira, Joshua Richman, Thaddeus W W Pace, Kelvin O Lim, Melissa A Polusny, Mark B Hamner, J Douglas Bremner, Mercy N Mumba, M Lindsey Jacobs, Patricia Pilkinton and 1 more

2 registry-linked trialsOpen access · greenAbstract read
In one paragraph

Article in Mindfulness, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01532999 nacompletednot on this map

A Multisite Randomized Controlled Trial of Mindfulness Meditation Therapy for PTSD

TypeinterventionalSponsorUS Department of Veterans AffairsRan2012 to 2014Enrolled254ConditionsPosttraumatic Stress DisorderArmsMindfulness Based Stress Reduction, Present Centered Group Therapy
NCT01548742 nacompletednot on this map

Meditation Interventions for Treatment of PTSD in Veterans

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2012 to 2014Enrolled116ConditionsStress Disorders, Post-TraumaticArmsMindfulness-Based Stress Reduction (MBSR), Present-Centered Group Therapy (PCGT)
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 1 country.

Itamar ShapiraSchool of Medicine, UAB Heersink School of Medicine, 1670 University Blvd, Birmingham, AL 35233, USA.ORCID 0000-0002-2175-6806
Joshua RichmanDepartment of Surgery, UAB Heersink School of Medicine, Birmingham, AL, USA.
Thaddeus W W PaceCollege of Nursing, University of Arizona, Tucson, AZ, USA.ORCID 0000-0002-0686-1413
Kelvin O LimDepartment of Psychiatry and Behavioral Science, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-2390-7268
Melissa A PolusnyDepartment of Psychiatry and Behavioral Science, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-4932-305X
Mark B HamnerRalph H. Johnson VA Medical Center, Charleston, SC, USA.ORCID 0000-0002-0532-8764
J Douglas BremnerDepartments of Psychiatry and Radiology, Emory University School of Medicine, Atlanta, GA, USA.
Mercy N MumbaResearch Service, Tuscaloosa VA Medical Center, Tuscaloosa, AL, USA.ORCID 0000-0002-9406-1757
M Lindsey JacobsResearch Service, Tuscaloosa VA Medical Center, Tuscaloosa, AL, USA.
Patricia PilkintonResearch Service, Tuscaloosa VA Medical Center, Tuscaloosa, AL, USA.
Lori L DavisResearch Service, Tuscaloosa VA Medical Center, Tuscaloosa, AL, USA.ORCID 0000-0002-6098-5986
University of Alabama · USUniversity of Minnesota · USBehavioral Pharma (United States) · USBirmingham VA Medical Center · USEmory University · USMedical University of South Carolina · USUniversity of Alabama at Birmingham · USUniversity of Arizona · US

Funding

Vascular Responses During Mental StressP01HL101398 · NHLBI · EMORY UNIVERSITY · PI SHEPS, DAVID SAMUEL · 2010 to 2015
$11.0M
Non-Invasive Vagal Nerve Stimulation in Patients with Opioid Use DisordersUH3DA048502 · NIDA · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS, INAN, OMER TOLGA · 2023 to 2025
$5.8M
Dopamine function, inflammation and connectivity in PTSDR01MH120262 · NIMH · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 2020 to 2023
$2.9M
A Mindfulness and Peer Mentoring Program to Improve Adherence to Medication Assisted Treatment for Opioid Use DisordersR33AT010802 · NCCIH · UNIVERSITY OF ALABAMA IN TUSCALOOSA · PI MUMBA, MERCY N · 2021 to 2023
$1.9M
Biological Correlates of Traumatic StressK24MH076955 · NIMH · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 2006 to 2013
$946k
Non-Invasive Vagal Nerve Stimulation in Patients with Opioid Use Disorders UG3DA048502 · NIDA · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS, INAN, OMER TOLGA · 2020 to 2021
$844k
A Multisite Randomized Controlled Trial of Mindfulness Meditation Therapy for PTSI01CX000687 · VA · TUSCALOOSA VETERANS AFFAIRS MEDICAL CTR · PI BREMNER, JAMES DOUGLAS, DAVIS, LORI L. · 2012 to 2013
–
Non-Invasive Vagal Nerve Stimulation in Veterans with Mild Traumatic Brain Injury (mTBI)I01RX003418 · VA · VETERANS HEALTH ADMINISTRATION · PI James Douglas Bremner · 2021 to 2026
–
CSRD VA I01 CX000683CSRD VA I01 CX000687CSRD VA I01 CX002331NCCIH NIH HHS R33 AT010802NHLBI NIH HHS P01 HL101398NIDA NIH HHS UG3 DA048502NIDA NIH HHS UH3 DA048502NIMH NIH HHS K24 MH076955NIMH NIH HHS R01 MH120262RRD VA I01 RX003418
6 · The paper itself

Abstract

Objectives: This study evaluates the effects of treatment with mindfulness-based stress reduction (MBSR) compared to the active control, present-centered group therapy (PCGT), on morning plasma cortisol, interleukin-6 (IL-6), and C-reactive protein (CRP) in veterans diagnosed with post-traumatic stress disorder (PTSD). Methods: In a post hoc exploratory analysis, we pooled biomarkers and clinical outcomes of mindfulness, PTSD, and depression from two randomized controlled trials comparing MBSR ( Results: Cortisol levels were inversely related to self-reported PTSD symptoms at baseline ( Conclusions: Increased mindfulness is associated with a recalibration of cortisol levels which may be indicative of therapeutic response, especially in patients with lower baseline cortisol. Furthermore, mindfulness-based practices improve symptoms of PTSD and depression in a significant correlation with self-reported levels of mindfulness. Clinical Trial Registration clinicaltrialsgov: NCT01532999 and NCT01548742.

Indexed as

CortisolInflammatory markersMeditationMindfulnessMindfulness-based stress reductionPost-traumatic stress disorderVeterans

Identifiers

PMID36938380
PMCPMC10022677
OpenAlexW4295733263

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.