Evidence map›Paper›PMID 36938147›Full record

ArticleTherapeutic advances in infectious disease

Previous corticosteroid exposure associates with an increased

Lilian Vargas Barahona, Kyle C Molina, Laura C Pedraza-Arévalo, Stefan Sillau, Alex Tagawa, Sias Scherger, Daniel B Chastain, Leland Shapiro, Jose Tuells, Carlos Franco-Paredes and 4 more

Open access · goldAbstract read
In one paragraph

Article in Therapeutic advances in infectious disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Current fungal infection reports · 2024
    Article
  7. Article
  8. Article
  9. Epidemiology, Risk Factors, and Prophylaxis Use forOpen forum infectious diseases · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 3 countries.

Lilian Vargas BarahonaDivision of Infectious Diseases, University of Colorado Anschutz Medical Campus, 12700 E. 19th Avenue, Mail Stop B168, Aurora, CO 80045, USA.ORCID https://orcid.org/0000-0003-3330-808X
Kyle C MolinaDivision of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Laura C Pedraza-ArévaloSt. Barnabas Hospital, Bronx, NY, USA.
Stefan SillauDepartment of Neurology, University of Colorado School of Medicine, Aurora, CO, USA.
Alex TagawaCenter for Gait and Movement Analysis (CGMA), Children's Hospital Colorado, Aurora, CO, USA.
Sias SchergerDivision of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Daniel B ChastainDepartment of Clinical and Administrative Pharmacy, University of Georgia College of Pharmacy, Albany, GA, USA.ORCID https://orcid.org/0000-0002-4018-0195
Leland ShapiroDivision of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Jose TuellsDepartment of Community Nursing, Preventive Medicine and Public Health and History of Science, University of Alicante, Alicante, Spain.
Carlos Franco-ParedesHospital Infantil de México Federico Gómez, México City, México.
Kellie L HawkinsDivision of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
James P MaloneyDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
George R ThompsonDivision of Infectious Diseases, University of California -Davis, Davis, CA, USA.
Andrés F Henao-MartínezDivision of Infectious Diseases, University of Colorado Anschutz Medical Campus, 12700 E. 19th Avenue, Mail Stop B168, Aurora, CO 80045, USA.ORCID https://orcid.org/0000-0001-7363-8652
University of Colorado Anschutz Medical Campus · USChildren's Hospital Colorado · USDenver Health Medical Center · USGeorgia College & State University · USHospital Infantil de México Federico Gómez · MXSt. Barnabas Hospital · USUniversity of Alicante · ESUniversity of California, Davis · USUniversity of Colorado Denver · USUniversity of Colorado Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: HIV-negative patients have substantial mortality from Objective: We aim to characterize the role of prior corticosteroid exposure in PJP-related mortality. Methods: We queried a global research network to identify adult HIV-negative patients with PJP with or without corticosteroid exposure in the preceding year before diagnosis ( Results: 1822 HIV-negative propensity-scored matched patients with prior corticosteroid exposure had significantly increased 10 weeks (16% Conclusion: Preceding corticosteroids in HIV-negative patients with PJP are associated with higher mortality. A higher fungal burden may influence corticosteroid-mediated mortality. Assessment of PJP prophylaxis must become a standard clinical best practice when instituting corticosteroid therapy courses.

Indexed as

corticosteroidsHIV-negative patientsimmunocompetentmortalityPneumocystis cariniiPneumocystis jirovecii

Identifiers

PMID36938147
PMCPMC10017958
OpenAlexW4324282929

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.