Evidence map›Paper›PMID 36938102›Full record

ArticleAdvances in orthopedics2023

Is the Combination of Platelet-Rich Plasma and Hyaluronic Acid the Best Injective Treatment for Grade II-III Knee Osteoarthritis? A Prospective Study.

Gianluca Ciapini, Matteo Simonettii, Michele Giuntoli, Giorgio Varchetta, Silvia De Franco, Edoardo Ipponi, Michelangelo Scaglione, Paolo Domenico Parchi

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in orthopedics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

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  6. Cross-Linked Versus Linear Hyaluronic Acid for Cartilage Repair in Rat Post-Traumatic Osteoarthritis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Gianluca CiapiniDepartment of Orthopedics and Trauma Surgery, University of Pisa, Pisa 56124, Italy.
Matteo SimonettiiDepartment of Orthopedics and Trauma Surgery, University of Pisa, Pisa 56124, Italy.
Michele GiuntoliDepartment of Orthopedics and Trauma Surgery, University of Pisa, Pisa 56124, Italy.ORCID https://orcid.org/0000-0001-7752-7706
Giorgio VarchettaDepartment of Orthopedics and Trauma Surgery, University of Pisa, Pisa 56124, Italy.
Silvia De FrancoDepartment of Orthopedics and Trauma Surgery, University of Pisa, Pisa 56124, Italy.ORCID https://orcid.org/0000-0002-6919-9703
Edoardo IpponiDepartment of Orthopedics and Trauma Surgery, University of Pisa, Pisa 56124, Italy.ORCID https://orcid.org/0000-0003-2107-6357
Michelangelo ScaglioneDepartment of Orthopedics and Trauma Surgery, University of Pisa, Pisa 56124, Italy.ORCID https://orcid.org/0000-0002-6143-1440
Paolo Domenico ParchiDepartment of Orthopedics and Trauma Surgery, University of Pisa, Pisa 56124, Italy.ORCID https://orcid.org/0000-0001-7560-7104
University of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Knee osteoarthritis is a common disease with increasing incidence and prevalence in western countries. It can cause severe pain and functional limitations, thereby representing a threat for patients' quality of life and a burden for national health systems. Intra-articular injections with hyaluronic acid (HA) and platelet-rich plasma (PRP) have been used for decades in order to reduce the symptoms caused by osteoarthritis. In recent years, a combination of HA and PRP has been introduced in clinical practice with the aim to minimize the clinical presentation of osteoarthritis and potentially delay articular degeneration. Materials and Methods: Sixty cases with grade II-III knee osteoarthritis according to the Kellgren-Lawrence classification were included in a prospective study, focused on the evaluation of clinical and functional outcomes after intra-articular knee injections. Cases were randomly divided into three groups. Twenty cases (Group Results: At 6-month follow-up, Group Conclusion: The combination of platelet-rich plasma and hyaluronic acid can be effective in the treatment of grade II-III knee osteoarthritis in a short-to-mid-term scenario. It represents an innovative and valuable alternative to the administration of its two components alone.

Identifiers

PMID36938102
PMCPMC10023227
OpenAlexW4323825482

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.