Evidence map›Paper›PMID 36938067›Full record

ArticleKidney international reports2023

The Diagnostic Conundrum of Glomerular Crescents With IgA Deposits.

Mineaki Kitamura, Salem Almaani, Bindu Challa, Mohankumar Doraiswamy, Isabelle Ayoub, Laura Biederman, Samir V Parikh, Ana Molovic-Kokovic, Jason Benedict, Nilesh Mhaskar and 4 more

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In one paragraph

Article in Kidney international reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mineaki KitamuraDivision of Renal and Transplant Pathology, Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Salem AlmaaniDivision of Nephrology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Bindu ChallaDivision of Renal and Transplant Pathology, Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Mohankumar DoraiswamyDepartment of Medicine, Mercy Hospital, Fort Smith, Arkansas, USA.
Isabelle AyoubDivision of Nephrology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Laura BiedermanDivision of Renal and Transplant Pathology, Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Samir V ParikhDivision of Nephrology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Ana Molovic-KokovicRochester General Hospital, Rochester, New York, USA.
Jason BenedictCenter for Biostatistics, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Nilesh MhaskarKettering Health, Kettering, Ohio, USA.
Zeid J KhitanMarshall University School of Medicine, Huntington, West Virginia, USA.
Sergey V BrodskyDivision of Renal and Transplant Pathology, Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Tibor NadasdyDivision of Renal and Transplant Pathology, Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Anjali A SatoskarDivision of Renal and Transplant Pathology, Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Glomerulonephritis (GN) with crescents and IgA deposits in kidney biopsy poses a frequent diagnostic and therapeutic dilemma because of multiple possibilities. Methods: Native kidney biopsies showing glomerular IgA deposition and crescents (excluding lupus nephritis) were identified from our biopsy archives between 2010 and 2021. Detailed clinicopathologic features were assessed. One-year clinical follow-up on a subset of cases was obtained. Results: A total of 285 cases were identified, and these clustered into IgA nephropathy (IgAN, Conclusion: Diagnostic overlap may remain unresolved in a substantial number of kidney biopsies with glomerular crescents and IgA deposits. A case-by-case approach, appropriate antibiotics if infection is ongoing, and consideration for cautious immunosuppressive treatment for progressive renal dysfunction may be needed for best chance of renal recovery.

Indexed as

ANCA vasculitiscrescentic necrotizing glomerulonephritisimmunoglobulin A nephropathyStaphylococcus infection–associated glomerulonephritis

Identifiers

PMID36938067
PMCPMC10014387

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