Evidence map›Paper›PMID 36937896›Full record

ReviewCritical care explorations2023

Pharmacologic Interventions to Prevent Delirium in Trauma Patients: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.

Gabriele Zitikyte, Danielle C Roy, Alexandre Tran, Shannon M Fernando, Erin Rosenberg, Salmaan Kanji, Paul T Engels, George A Wells, Christian Vaillancourt

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Critical care explorations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 4 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Guideline
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Gabriele ZitikyteSchool of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, ON, Canada.
Danielle C RoySchool of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, ON, Canada.
Alexandre TranSchool of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, ON, Canada.
Shannon M FernandoClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Erin RosenbergDivision of Critical Care, Department of Medicine, University of Ottawa, Ottawa, ON, Canada.
Salmaan KanjiClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Paul T EngelsDepartment of Surgery, McMaster University, Hamilton, ON, Canada.
George A WellsSchool of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, ON, Canada.
Christian VaillancourtSchool of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, ON, Canada.
University of Ottawa · CAOttawa Hospital Research InstituteMcMaster University · CAOttawa Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To compare the relative efficacy of pharmacologic interventions in the prevention of delirium in ICU trauma patients. DATA SOURCES: We searched Medical Literature Analysis and Retrieval System Online, Embase, and Cochrane Registry of Clinical Trials from database inception until June 7, 2022. We included randomized controlled trials comparing pharmacologic interventions in critically ill trauma patients. STUDY SELECTION: Two reviewers independently screened studies for eligibility, extracted data, and assessed risk of bias. DATA EXTRACTION: Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines for network analysis were followed. Random-effects models were fit using a Bayesian approach to network meta-analysis. Between-group comparisons were estimated using hazard ratios (HRs) for dichotomous outcomes and mean differences for continuous outcomes, each with 95% credible intervals. Treatment rankings were estimated for each outcome in the form of surface under the cumulative ranking curve values. DATA SYNTHESIS: A total 3,541 citations were screened; six randomized clinical trials (

conclusionsThe results of this network meta-analysis suggest that there is no difference found between pharmacologic interventions on delirium occurrence, length of ICU stay, length of hospital stay, or mortality, in trauma ICU patients.

Indexed as

critical caredeliriumdexmedetomidinepropofolsystematic reviewtrauma

Identifiers

PMID36937896
PMCPMC10019141
OpenAlexW4324332739

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.