Evidence map›Paper›PMID 36937689›Full record

ReviewFrontiers in neuroscience2023

The connection between heart rate variability (HRV), neurological health, and cognition: A literature review.

Xianghong Arakaki, Rebecca J Arechavala, Elizabeth H Choy, Jayveeritz Bautista, Bishop Bliss, Cathleen Molloy, Daw-An Wu, Shinsuke Shimojo, Yang Jiang, Michael T Kleinman and 1 more

3 registry-linked trialsOpen access · goldFull text readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 85 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 3 pooled it
36.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06695715 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Heart Rate Variability Biofeedback, Interoceptive Training, and Mindfulness on Stress Reduction in the University of Seville Academic Community (Faculty, Administrative Staff, and Students)

TypeinterventionalSponsorUniversity of SevilleRan2025 to 2026Enrolled120ConditionsStress, AnxietyArmsMindfulness Training Program, HRV Biofeedback, Interoception Training
NCT06723743 narecruitingnot on this mapstarted 2026, after this paper: background citation

Transcutaneous Auricular Vagus Nerve Stimulation Effects on Attention and Working Memory: A Pilot Study

TypeinterventionalSponsorBaylor College of MedicineRan2026 to 2027Enrolled30ConditionsTraumatic Brain Injury (TBI) PatientsArmsTranscutaneous vagus nerve stimulation for attention in veterans with TBI, Soterix Medical Vagus Nerve Stimulation mini-CT
NCT07443072 recruitingnot on this mapstarted 2026, after this paper: background citation

Heart Rate Variability and Processed EEG Features as Predictors of Postoperative Outcomes After Cranial Neurosurgery - A Prospective Observational Study in the Post-Anesthesia Care Unit

TypeobservationalSponsorFondazione I.R.C.C.S. Istituto Neurologico Carlo BestaRan2026 to 2027Enrolled300ConditionsCranial Neurosurgery
3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 3 syntheses or guidelines pooled it, 167 citations in OpenAlex.

  1. Pooled it
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  10. Association Between Carotid Arterial Strain and Heart Rate Variability in Older Age.Journal of clinical hypertension (Greenwich, Conn.) · 2026
    Article
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  12. Review
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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Xianghong ArakakiCognition and Brain Integration Laboratory, Department of Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, United States.
Rebecca J ArechavalaDepartment of Environmental and Occupational Health, University of California, Irvine, Irvine, CA, United States.
Elizabeth H ChoyDepartment of Environmental and Occupational Health, University of California, Irvine, Irvine, CA, United States.
Jayveeritz BautistaDepartment of Environmental and Occupational Health, University of California, Irvine, Irvine, CA, United States.
Bishop BlissDepartment of Environmental and Occupational Health, University of California, Irvine, Irvine, CA, United States.
Cathleen MolloyCognition and Brain Integration Laboratory, Department of Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, United States.
Daw-An WuDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, United States.
Shinsuke ShimojoDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, United States.
Yang JiangDepartment of Behavioral Science, College of Medicine, University of Kentucky, Lexington, KY, United States.
Michael T KleinmanDepartment of Environmental and Occupational Health, University of California, Irvine, Irvine, CA, United States.
Robert A KlonerCardiovascular Research, Huntington Medical Research Institutes, Pasadena, CA, United States.
University of California, Irvine · USHuntington Medical Research Institutes · USCalifornia Institute of Technology · USUniversity of Kentucky · US

Funding

Cognitive challenge to reveal systemic neurophysiology biomarkers in pre-symptomatic Alzheimer’s diseaseR01AG063857 · NIA · HUNTINGTON MEDICAL RESEARCH INSTITUTES · PI ARAKAKI, XIANGHONG, KLONER, ROBERT A · 2021 to 2025
$3.8M
Cognitive challenge to reveal presymptomatic Alzheimer's diseaseR56AG063857 · NIA · HUNTINGTON MEDICAL RESEARCH INSTITUTES · PI ARAKAKI, XIANGHONG, HARRINGTON, MICHAEL GORDON · 2019 to 2019
$513k
NIA NIH HHS R01 AG063857
6 · The paper itself

Abstract

The heart and brain have bi-directional influences on each other, including autonomic regulation and hemodynamic connections. Heart rate variability (HRV) measures variation in beat-to-beat intervals. New findings about disorganized sinus rhythm (erratic rhythm, quantified as heart rate fragmentation, HRF) are discussed and suggest overestimation of autonomic activities in HRV changes, especially during aging or cardiovascular events. When excluding HRF, HRV is regulated

Indexed as

cognitionerratic sinus rhythmheart and brainheart rate fragmentationheart rate variabilityinhibitory controlneurological conditionsvagal functioning

Identifiers

PMID36937689
PMCPMC10014754
OpenAlexW4322744506

What OpenQuestion holds

Textfull text, public
LicenceCC BY
reference markers read6
measurements read5
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.