Evidence map›Paper›PMID 36937673›Full record

ReviewFrontiers in neuroscience2023

The effects of resistance exercise on cognitive function, amyloidogenesis, and neuroinflammation in Alzheimer's disease.

Caroline Vieira Azevedo, Debora Hashiguchi, Henrique Correia Campos, Emilly V Figueiredo, Sthefanie Ferreira S D Otaviano, Arlete Rita Penitente, Ricardo Mario Arida, Beatriz Monteiro Longo

Open access · goldFull text readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.

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  4. A peripheral perspective on brain health: vascular and skeletal muscle contributions.American journal of physiology. Heart and circulatory physiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Caroline Vieira AzevedoDepartment of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil.
Debora HashiguchiDepartment of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil.
Henrique Correia CamposDepartment of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil.
Emilly V FigueiredoDepartment of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil.
Sthefanie Ferreira S D OtavianoDepartment of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil.
Arlete Rita PenitenteDepartment of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil.
Ricardo Mario AridaDepartment of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil.
Beatriz Monteiro LongoDepartment of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil.
Universidade Federal de São Paulo · BRUniversidade Federal do Rio Grande do Norte · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the increasing prevalence of Alzheimer's disease (AD) and difficulties in finding effective treatments, it is essential to discover alternative therapies through new approaches. In this regard, non-pharmacological therapies, such as physical exercise, have been proposed and explored for the treatment of AD. Recent studies have suggested that resistance exercise (RE) is an effective strategy for promoting benefits in memory and cognitive function, producing neuroprotective and anti-inflammatory effects, and reducing amyloid load and plaques, thereby reducing the risk, and alleviating the neurodegeneration process of AD and other types of dementia in the elderly. In addition, RE is the exercise recommended by the World Health Organization for the elderly due to its benefits in improving muscle strength and balance, and increasing autonomy and functional capacity, favoring improvements in the quality of life of the elderly population, who is more likely to develop AD and other types of dementia. In this mini-review, we discuss the impact of RE on humans affected by MCI and AD, and animal models of AD, and summarize the main findings regarding the effects of RE program on memory and cognitive functions, neurotrophic factors, Aβ deposition and plaque formation, as well as on neuroinflammation. Overall, the present review provides clinical and preclinical evidence that RE plays a role in alleviating AD symptoms and may help to understand the therapeutic potential of RE, thereby continuing the advances in AD therapies.

Indexed as

Alzheimer’s diseaseanimal models of ADneuroprotectionpatients with ADresistant physical exercise

Identifiers

PMID36937673
PMCPMC10017453
OpenAlexW4322773103

What OpenQuestion holds

Textfull text, public
LicenceCC BY
reference markers read3
measurements read13
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.