ArticleFrontiers in neuroscience2023
Association between brain structures and migraine: A bidirectional Mendelian randomization study.
Article in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- A Bidirectional Mendelian Randomization Study of Causal Relationships Between Migraine and White-Matter Structural Connectivity.Journal of pain research · 2025Article
- Causal relationships between cortical brain structural alterations and migraine subtypes: a bidirectional Mendelian randomization study of 2,347 neuroimaging phenotypes.The journal of headache and pain · 2024Article
- The TRPA1 Ion Channel Mediates Oxidative Stress-Related Migraine Pathogenesis.Molecules (Basel, Switzerland) · 2024Review
- Genetic evidence for the causal relationships between migraine, dementia, and longitudinal brain atrophy.The journal of headache and pain · 2024Article
- Assessing the Causal Relationship between Genetically Determined Inflammatory Cytokines and Parkinson's Disease Risk: A Bidirectional Two-Sample Mendelian Randomization Study.Journal of immunology research · 2024Article
- Association between physical frailty and cortical structure in middle-aged and elderly people: a Mendelian randomization study.Frontiers in aging neuroscience · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Accumulating evidence of clinical and neuroimaging studies indicated that migraine is related to brain structural alterations. However, it is still not clear whether the associations of brain structural alterations with migraine are likely to be causal, or could be explained by reverse causality confounding. Methods: We carried on a bidirectional Mendelian randomization analysis in order to identify the causal relationship between brain structures and migraine risk. Summary-level data and independent variants used as instruments came from large genome-wide association studies of total surface area and average thickness of cortex (33,992 participants), gray matter volume (8,428 participants), white matter hyperintensities (50,970 participants), hippocampal volume (33,536 participants), and migraine (102,084 cases and 771,257 controls). Results: We identified suggestive associations of the decreased surface area (OR = 0.85; 95% CI, 0.75-0.96; Conclusion: We provided suggestive evidence that surface area and hippocampal volume are causally associated with migraine risk.
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