ArticleChemical science2023
Nitrogen atom insertion into indenes to access isoquinolines.
Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Direct access to 2-imidazolines from unactivated alkenes.Chemical science · 2026Article
- Nitrogen atom insertion and related skeletal editing strategies in aromatic heterocycles for drug discovery (2015-2025).Molecular diversity · 2026Review
- Skeletal Editing via Diastereoselective Ring Expansion Enables Enantioenriched Tetrasubstituted ΔJACS Au · 2026Article
- Article
- Oxygen migration into carbon-carbon single bonds by photochemical oxidation.Nature synthesis · 2026Article
- Core diversification using 1,2-oxaborines as a versatile molecular platform.Nature chemistry · 2026Article
- Skeletal Editing by Tip-Induced Chemistry.Journal of the American Chemical Society · 2025Article
- Carbon-to-nitrogen atom swap enables direct access to benzimidazoles from drug-like indoles.Nature chemistry · 2025Article
- Iodonitrene-Mediated Nitrogen Transfer to Alkenes for the Direct Synthesis of NH-Aziridines.Journal of the American Chemical Society · 2025Article
- Structurally Constrained Cyclic (Diacyloxyiodo)Arenes as an Enabling Platform for Hypervalent Iodine(III) Chemistry.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Regioretention Probes Distinguish Ring Scission Mechanisms in Nitrogen Insertion Reactions.Tetrahedron letters · 2025Article
- Precise control of selective nitrogen atom insertion into five-membered cyclic β-ketoesters.Nature communications · 2025Article
- N-Insertion of Diazonium Salts Into Ketone Derivatives.Angewandte Chemie (International ed. in English) · 2025Article
- Chemodivergent C-to-N atom swap from benzofurans to benzisoxazoles and benzoxazoles.Chemical science · 2025Article
- Dibenzothiophenium Salts: Practical Alternatives to Hypervalent I(III)-Based Reagents.Accounts of chemical research · 2025Article
- Redox-Tunable Ring Expansion Enabled By A Single-Component Electrophilic Nitrogen Atom Synthon.Angewandte Chemie (International ed. in English) · 2025Article
- Interrogation of Enantioselectivity in the Photomediated Ring Contractions of Saturated Heterocycles.Journal of the American Chemical Society · 2025Article
- Single-Carbon Insertion into Single C-C Bonds with Diazirines.Journal of the American Chemical Society · 2025Article
- Skeletal Editing of Mechanically Interlocked Molecules: Nitrogen Atom Deletion from Crown Ether-Dibenzylammonium Rotaxanes.Journal of the American Chemical Society · 2024Article
- Rh-Catalyzed Enantioselective Single-Carbon Insertion of Alkenes.Journal of the American Chemical Society · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a convenient protocol for a nitrogen atom insertion into indenes to afford isoquinolines. The reaction uses a combination of commercially available phenyliodine(iii) diacetate (PIDA) and ammonium carbamate as the nitrogen source to furnish a wide range of isoquinolines. Various substitution patterns and commonly used functional groups are well tolerated. The operational simplicity renders this protocol broadly applicable and has been successfully extended towards the direct interconversion of cyclopentadienes into the corresponding pyridines. Furthermore, this strategy enables the facile synthesis of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.