Evidence map›Paper›PMID 36937570›Full record

ReviewFrontiers in synaptic neuroscience2023

Calcium signaling in astrocytes and gliotransmitter release.

Julianna Goenaga, Alfonso Araque, Paulo Kofuji, Daniela Herrera Moro Chao

Open access · goldFull text readReview
In one paragraph

Review in Frontiers in synaptic neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
18.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 127 citations in OpenAlex.

  1. Review
  2. Context-Dependent modulation of astrocytic CaJournal of computational neuroscience · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Functional CaScientific reports · 2026
    Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Mitochondrial CaBiomolecules · 2026
    Review
  18. Review
  19. Review
  20. Designing Neural Dynamics: From Digital Twin Modeling to Regeneration.International journal of molecular sciences · 2025
    Review

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Julianna GoenagaDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, United States.
Alfonso AraqueDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, United States.
Paulo KofujiDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, United States.
Daniela Herrera Moro ChaoDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, United States.
University of Minnesota · US

Funding

Predoctoral Training of NeuroscientistsT32NS105604 · NINDS · UNIVERSITY OF MINNESOTA · PI A DAVID REDISH · 2018 to 2026
$3.5M
Astrocyte activity in amygdala-related fear conditioned behaviorsR01MH119355 · NIMH · UNIVERSITY OF MINNESOTA · PI ARAQUE, ALFONSO, KOFUJI, PAULO · 2020 to 2024
$2.3M
Role of astrocytes in dopamine signaling and psychostimulant effectsR01DA048822 · NIDA · UNIVERSITY OF MINNESOTA · PI ARAQUE, ALFONSO · 2019 to 2023
$1.8M
Estrogen Signaling in Nucleus Accumbens AstrocytesF31NS124107 · NINDS · UNIVERSITY OF MINNESOTA · PI GOENAGA, JULIANNA G · 2022 to 2024
$89k
NIDA NIH HHS R01 DA048822NIMH NIH HHS R01 MH119355NINDS NIH HHS F31 NS124107NINDS NIH HHS T32 NS105604
6 · The paper itself

Abstract

Glia are as numerous in the brain as neurons and widely known to serve supportive roles such as structural scaffolding, extracellular ionic and neurotransmitter homeostasis, and metabolic support. However, over the past two decades, several lines of evidence indicate that astrocytes, which are a type of glia, play active roles in neural information processing. Astrocytes, although not electrically active, can exhibit a form of excitability by dynamic changes in intracellular calcium levels. They sense synaptic activity and release neuroactive substances, named gliotransmitters, that modulate neuronal activity and synaptic transmission in several brain areas, thus impacting animal behavior. This "dialogue" between astrocytes and neurons is embodied in the concept of the tripartite synapse that includes astrocytes as integral elements of synaptic function. Here, we review the recent work and discuss how astrocytes

Indexed as

astrocytecalcium signalinggliotransmissionplasticitytripartite synapse

Identifiers

PMID36937570
PMCPMC10017551
OpenAlexW4322773221

What OpenQuestion holds

Textfull text, public
LicenceCC BY
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.