Evidence map›Paper›PMID 36937549›Full record

ArticleInternational journal of nanomedicine2023

Copperphosphotungstate Doped Polyanilines Nanorods for GSH-Depletion Enhanced Chemodynamic/NIR-II Photothermal Synergistic Therapy.

Sheng Ye, Huichun Xiao, Jian Chen, Di Zhang, Li Qi, Ting Peng, Yanyang Gao, Qianbing Zhang, Jinqing Qu, Lei Wang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 63% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Sheng YeGuangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.
Huichun XiaoGuangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.
Jian ChenGuangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.ORCID 0000-0003-4189-7697
Di ZhangGuangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.
Li QiGuangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.
Ting PengSchool of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, Guangdong, People's Republic of China.
Yanyang GaoSchool of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, Guangdong, People's Republic of China.
Qianbing ZhangCancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.
Jinqing QuSchool of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, Guangdong, People's Republic of China.
Lei WangCollege of Materials and Chemical Engineering, Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials, China Three Gorges University, Yichang, People's Republic of China.
Ruiyuan LiuGuangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.ORCID 0000-0002-6696-8351
Southern Medical University · CNSouth China University of Technology · CNChina Three Gorges University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The high concentration of glutathione (GSH) and hydrogen peroxide (H Methods: The copperphosphotungstate was incorporated into polyanilines to design copperphosphotungstate doped polyaniline nanorods (CuPW@PANI Nanorods) via chemical oxidant polymerization of aniline. The low long-term toxicity and biocompatibility were evaluated. Both in vitro and in vivo experiments were carried out to confirm the GSH depletion enhanced CDT/NIR-II PTT synergistic therapy. Results: CuPW@PANI Nanorods feature biosafety and biocompatibility, strong NIR-II absorbance, and high photothermal-conversion efficiency (45.14%) in NIR-II bio-window, making them highly applicable for photoacoustic imaging and NIR-II PTT. Moreover, CuPW@PANI Nanorods could consume endogenous GSH to disrupt redox homeostasis and perform a Fenton-like reaction with H Conclusion: This study provides a proof of concept of GSH-depletion augmented chemodynamic/NIR-II photothermal therapy.

Indexed as

NanoparticlesNanotubesNeoplasmsAniline CompoundsCell Line, TumorGlutathioneHumansHydrogen PeroxidePhotothermal TherapyTumor MicroenvironmentAniline CompoundsGlutathioneHydrogen Peroxidepolyanilinechemodynamic therapycopperphosphotungstateGSH depletionNIR-II absorption nanorodsNIR-II photothermal therapysynergistic therapy

Identifiers

PMID36937549
PMCPMC10019345
OpenAlexW4323923619

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.