Evidence map›Paper›PMID 36937534›Full record

ArticleFrontiers in neurology2023

Gait and turning characteristics from daily life increase ability to predict future falls in people with Parkinson's disease.

Vrutangkumar V Shah, Adam Jagodinsky, James McNames, Patricia Carlson-Kuhta, John G Nutt, Mahmoud El-Gohary, Kristen Sowalsky, Graham Harker, Martina Mancini, Fay B Horak

Open access · goldFull text read
In one paragraph

Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
10.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

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  14. Assessing fall risk in multiple sclerosis using patient-reported outcomes and wearable gait metrics.Multiple sclerosis journal - experimental, translational and clinical
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Vrutangkumar V ShahDepartment of Neurology, Oregon Health & Science University, Portland, OR, United States.
Adam JagodinskyAPDM Wearable Technologies, A Clario Company, Portland, OR, United States.
James McNamesAPDM Wearable Technologies, A Clario Company, Portland, OR, United States.
Patricia Carlson-KuhtaDepartment of Neurology, Oregon Health & Science University, Portland, OR, United States.
John G NuttDepartment of Neurology, Oregon Health & Science University, Portland, OR, United States.
Mahmoud El-GoharyAPDM Wearable Technologies, A Clario Company, Portland, OR, United States.
Kristen SowalskyAPDM Wearable Technologies, A Clario Company, Portland, OR, United States.
Graham HarkerDepartment of Neurology, Oregon Health & Science University, Portland, OR, United States.
Martina ManciniDepartment of Neurology, Oregon Health & Science University, Portland, OR, United States.
Fay B HorakDepartment of Neurology, Oregon Health & Science University, Portland, OR, United States.
Oregon Health & Science University · USPortland State University · US

Funding

Mobility Life: Monitoring Mobility in Daily Lives of People with Neurological DiseaseR44AG055388 · NIA · APDM, INC. · PI EL-GOHARY, MAHMOUD, HORAK, FAY BAHLING · 2016 to 2019
$2.9M
Mobility in Daily Life and Falls in Parkinson's Disease: Potential for RehabilitationR01HD100383 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI HORAK, FAY BAHLING, MANCINI, MARTINA · 2020 to 2024
$2.6M
Monitoring Balance and Gait Disorders in Parkinson???s Disease with the Home ObjeR43AG044863 · NIA · APDM, INC. · PI EL-GOHARY, MAHMOUD, HORAK, FAY BAHLING · 2013 to 2014
$699k
NIA NIH HHS R43 AG044863NIA NIH HHS R44 AG055388NICHD NIH HHS R01 HD100383
6 · The paper itself

Abstract

Objectives: To investigate if digital measures of gait (walking and turning) collected passively over a week of daily activities in people with Parkinson's disease (PD) increases the discriminative ability to predict future falls compared to fall history alone. Methods: We recruited 34 individuals with PD (17 with history of falls and 17 non-fallers), age: 68 ± 6 years, MDS-UPDRS III ON: 31 ± 9. Participants were classified as fallers (at least one fall) or non-fallers based on self-reported falls in past 6 months. Eighty digital measures of gait were derived from 3 inertial sensors (Opal Results: Twenty-five subjects reported falls in the follow-up year. Quantity of gait and turning measures (e.g., number of gait bouts and turns per hour) were similar in future fallers and non-fallers. The AUC to discriminate future fallers from non-fallers using fall history alone was 0.77 (95% CI: [0.50-1.00]). In contrast, the highest AUC for gait and turning digital measures with 4 combinations was 0.94 [0.84-1.00]. From the top 10 models (all AUCs>0.90) via the best subsets strategy, the most consistently selected measures were variability of toe-out angle of the foot (9 out of 10), pitch angle of the foot during mid-swing (8 out of 10), and peak turn velocity (7 out of 10). Conclusions: These findings highlight the importance of considering precise digital measures, captured

Indexed as

daily lifefuture fallsgaitinertial sensorsParkinson's diseaseturning

Identifiers

PMID36937534
PMCPMC10015637
OpenAlexW4322735783

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read10
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.