Evidence map›Paper›PMID 36937038›Full record

ArticleJournal of thrombosis and circulation: open access2018

M D Zielinski, J R Stubbs, S F Polites, A Xue, Dal Haugen, R Emery, D H Jenkins, M S Park

Abstract read
In one paragraph

Article in Journal of thrombosis and circulation: open access, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

M D ZielinskiDivision of Trauma, Critical Care and General Surgery, St. Mary's Hospital, Mayo Clinic, USA.
J R StubbsLaboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
S F PolitesDivision of Trauma, Critical Care and General Surgery, St. Mary's Hospital, Mayo Clinic, USA.
A XueDepartment of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Dal HaugenDepartment of Anesthesiology, Mayo Clinic, Rochester, Minnesota, USA.
R EmeryLaboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
D H JenkinsDivision of Trauma, Emergency Surgery, University of Texas Health Science Center, San Antonio, Texas, USA.
M S ParkDivision of Trauma, Critical Care and General Surgery, St. Mary's Hospital, Mayo Clinic, USA.

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Analysis and Characterization of Trauma-Induced CoagulopathyUM1HL120877 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI MORRISSEY, JAMES H., WISNIEWSKI, STEPHEN R · 2013 to 2019
$26.6M
Microvesicle production after trauma & its Clinical Impact on VenothromboembolismK08GM093133 · NIGMS · MAYO CLINIC ROCHESTER · PI PARK, MYUNG SOO · 2010 to 2014
$614k
NCATS NIH HHS UL1 TR000135NHLBI NIH HHS UM1 HL120877NIGMS NIH HHS K08 GM093133
6 · The paper itself

Abstract

Background: Warm fresh whole blood (WFWB) is an ideal resuscitation fluid for exsanguinating patients but there are myriad logistic and infectious issues associated with its use. Cold whole blood (CWB) may be an acceptable alternative to the reconstituted whole blood (RWB), the current standard of care. A leukoreduction filter has been developed which maintains platelet count while eliminating white blood cells but its effect on platelet function is unknown. We hypothesize that CWB will retain an acceptable functional coagulation profile after filtration and over time. Study Design and Methods: WFWB and CWB samples were obtained from eight donors and four units of RWB were created. The quantitative and qualitative Results: Filtration was successful at removing white blood cells (5.5 ± 1.2 Conclusion: CWB holds great promise as a surrogate for WFWB, but use of a platelet-sparing LR filter diminishes platelet function almost immediately after filtration.

Indexed as

CoagulationHemostaticLeukoreductionPlateletThromboelastography

Identifiers

PMID36937038
PMCPMC10022254

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.