Evidence map›Paper›PMID 36936990›Full record

ArticleFrontiers in molecular biosciences2023

Enhancing response of a protein conformational switch by using two disordered ligand binding domains.

Harsimranjit Sekhon, Jeung-Hoi Ha, Stewart N Loh

Open access · goldFull text read
In one paragraph

Article in Frontiers in molecular biosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Seesaw protein: Design of a protein that adopts interconvertible alternative functional conformations and its dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Harsimranjit SekhonDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, United States.
Jeung-Hoi HaDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, United States.
Stewart N LohDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, United States.
SUNY Upstate Medical University · US

Funding

Combining protein and DNA engineering to create bioswitchesR01GM148448 · NIGMS · UPSTATE MEDICAL UNIVERSITY · PI LOH, STEWART N · 2022 to 2025
$1.6M
Molecular Devices for the Detection and Treatment of HCMV InfectionF30GM146428 · NIGMS · UPSTATE MEDICAL UNIVERSITY · PI Harsimranjit S Sekhon · 2022 to 2026
$268k
NIGMS NIH HHS F30 GM146428NIGMS NIH HHS R01 GM148448
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

allosteryalternate frame foldingloop closure entropymutually exclusive foldingprotein engineering

Identifiers

PMID36936990
PMCPMC10018487
OpenAlexW4322774638

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read71
identifiers read1
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.