Evidence map›Paper›PMID 36936814›Full record

ArticleComputational and structural biotechnology journal2023

Apically-located P4-ATPase1-Lem1 complex internalizes phosphatidylserine and regulates motility-dependent invasion and egress in

Kai Chen, Xiyu Huang, Ute Distler, Stefan Tenzer, Özlem Günay-Esiyok, Nishith Gupta

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.5field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Kai ChenDepartment of Molecular Parasitology, Faculty of Life Sciences, Humboldt University, Berlin, Germany.
Xiyu HuangDepartment of Molecular Parasitology, Faculty of Life Sciences, Humboldt University, Berlin, Germany.
Ute DistlerInstitute of Immunology, University Medical Center of the Johannes-Gutenberg University, Mainz, Germany.
Stefan TenzerInstitute of Immunology, University Medical Center of the Johannes-Gutenberg University, Mainz, Germany.
Özlem Günay-EsiyokDepartment of Molecular Parasitology, Faculty of Life Sciences, Humboldt University, Berlin, Germany.
Nishith GuptaDepartment of Molecular Parasitology, Faculty of Life Sciences, Humboldt University, Berlin, Germany.
Humboldt-Universität zu Berlin · DEJohannes Gutenberg University Mainz · DE

Funding

DBT-Wellcome Trust India Alliance IA/S/19/1/504263
6 · The paper itself

Abstract

The membrane asymmetry regulated by P4-ATPases is crucial for the functioning of eukaryotic cells. The underlying spatial translocation or flipping of specific lipids is usually assured by respective P4-ATPases coupled to conforming non-catalytic subunits. Our previous work has identified five P4-ATPases (

Indexed as

BSA, bovine serum albuminCdc50CDC50, Cell Division Control 50cGMP, cyclic Guanosine MonophosphateCOS, crossover sequenceDAPI, 4′,6-diamidino-2-phenylindoleDHFR-TS, dihydrofolate reductase – thymidylate synthaseHFF, human foreskin fibroblastHXGPRT, hypoxanthine-xanthine-guanine phosphoribosyltransferaseIAA, indole-3-acetic acidLem1LEM, Ligand Effector ModulemAID, (mini) auxin-inducible degronNBD-lipidNBD, nitrobenzoxadiazoleP4-ATPase1PBS, phosphate-buffered salinePhosphatidylserinePhospholipid flippingPtdCho, phosphatidylcholinePtdEtn, phosphatidylethanolaminePtdSer, phosphatidylserinePtdThr, phosphatidylthreonineUTR, untranslated region

Identifiers

PMID36936814
PMCPMC10015115
OpenAlexW4321378266

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read123
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.