Evidence map›Paper›PMID 36936603›Full record

ArticleBrain hemorrhages2022

Gene expression changes implicate specific peripheral immune responses to Deep and Lobar Intracerebral Hemorrhages in humans.

Bodie Knepp, Bradley P Ander, Glen C Jickling, Heather Hull, Alan H Yee, Kwan Ng, Fernando Rodriguez, Paulina Carmona-Mora, Hajar Amini, Xinhua Zhan and 4 more

Open access · diamondFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain hemorrhages, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Molecular heterogeneity in human stroke - What can we learn from the peripheral blood transcriptome?Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Bodie KneppDepartment of Neurology, School of Medicine, University of California at Davis, Sacramento, CA, USA.
Bradley P AnderDepartment of Neurology, School of Medicine, University of California at Davis, Sacramento, CA, USA.
Glen C JicklingDepartment of Medicine, Division of Neurology, University of Alberta, Edmonton, Canada.
Heather HullDepartment of Neurology, School of Medicine, University of California at Davis, Sacramento, CA, USA.
Alan H YeeDepartment of Neurology, School of Medicine, University of California at Davis, Sacramento, CA, USA.
Kwan NgDepartment of Neurology, School of Medicine, University of California at Davis, Sacramento, CA, USA.
Fernando RodriguezDepartment of Neurology, School of Medicine, University of California at Davis, Sacramento, CA, USA.
Paulina Carmona-MoraDepartment of Neurology, School of Medicine, University of California at Davis, Sacramento, CA, USA.
Hajar AminiDepartment of Neurology, School of Medicine, University of California at Davis, Sacramento, CA, USA.
Xinhua ZhanDepartment of Neurology, School of Medicine, University of California at Davis, Sacramento, CA, USA.
Marisa HakoupianDepartment of Neurology, School of Medicine, University of California at Davis, Sacramento, CA, USA.
Noor AlomarDepartment of Neurology, School of Medicine, University of California at Davis, Sacramento, CA, USA.
Frank R SharpDepartment of Neurology, School of Medicine, University of California at Davis, Sacramento, CA, USA.
Boryana StamovaDepartment of Neurology, School of Medicine, University of California at Davis, Sacramento, CA, USA.
University of California, Davis · USUniversity of Alberta · CA

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Gina M Dayton · 2002 to 2026
$84.9M
Molecular Biology of Stroke in HumansR01NS075035 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SHARP, FRANK R · 2012 to 2016
$3.1M
Genomics of Intracerebral Hemorrhage and its CausesR01NS106950 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ANDER, BRADLEY PEARCE, SHARP, FRANK R · 2019 to 2023
$3.0M
Whole Genome RNA Sequencing (RNAseq) of Blood from Patients with Lacunar StrokeR01NS101718 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SHARP, FRANK R, STAMOVA, BORYANA · 2017 to 2021
$3.0M
Whole Transcriptome Studies of Patients with Transient Ischemic Attacks (TIAs)R01NS097000 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SHARP, FRANK R, STAMOVA, BORYANA · 2016 to 2020
$2.8M
Biomarker Signatures for Delayed Cerebral Ischemia and Outcome Following Subarachnoid HemorrhageR61NS119345 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ANDER, BRADLEY PEARCE, SHARP, FRANK R · 2021 to 2023
$2.0M
Biomarker Signatures for Delayed Cerebral Ischemia and Outcome Following Subarachnoid HemorrhageR33NS119345 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ANDER, BRADLEY PEARCE, SHARP, FRANK R · 2024 to 2025
$1.1M
NCI NIH HHS P30 CA093373NINDS NIH HHS R01 NS075035NINDS NIH HHS R01 NS097000NINDS NIH HHS R01 NS101718NINDS NIH HHS R01 NS106950NINDS NIH HHS R33 NS119345NINDS NIH HHS R61 NS119345
6 · The paper itself

Abstract

The peripheral immune system response to Intracerebral Hemorrhage (ICH) may differ with ICH in different brain locations. Thus, we investigated peripheral blood mRNA expression of Deep ICH, Lobar ICH, and vascular risk factor-matched control subjects (n = 59). Deep ICH subjects usually had hypertension. Some Lobar ICH subjects had cerebral amyloid angiopathy (CAA). Genes and gene networks in Deep ICH and Lobar ICH were compared to controls. We found 774 differentially expressed genes (DEGs) and 2 co-expressed gene modules associated with Deep ICH, and 441 DEGs and 5 modules associated with Lobar ICH. Pathway enrichment showed some common immune/inflammatory responses between locations including Autophagy, T Cell Receptor, Inflammasome, and Neuroinflammation Signaling. Th2, Interferon, GP6, and BEX2 Signaling were unique to Deep ICH. Necroptosis Signaling, Protein Ubiquitination, Amyloid Processing, and various RNA Processing terms were unique to Lobar ICH. Finding amyloid processing pathways in blood of Lobar ICH patients suggests peripheral immune cells may participate in processes leading to perivascular/vascular amyloid in CAA vessels and/or are involved in its removal. This study identifies distinct peripheral blood transcriptome architectures in Deep and Lobar ICH, emphasizes the need for considering location in ICH studies/clinical trials, and presents potential location-specific treatment targets.

Indexed as

AmyloidBloodDeep hemorrhageIntracerebral hemorrhageLobar hemorrhageNeutrophilsRNA expressionT Cells

Identifiers

PMID36936603
PMCPMC10019834
OpenAlexW4224302797

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read41
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.