ArticleBMJ medicine2022
Severity of maternal SARS-CoV-2 infection and perinatal outcomes of women admitted to hospital during the omicron variant dominant period using UK Obstetric Surveillance System data: prospective, national cohort study.
Article in BMJ medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Antenatal and neonatal exposure to SARS-CoV-2 and children's development: a systematic review and meta-analysis.Pediatric research · 2024Pooled it
- The Role of Vaccination in Maternal and Perinatal Outcomes Associated With COVID-19 in Pregnancy.JAMA · 2026Article
- Use of evidence from the UK Obstetric Surveillance System in policy and clinical practice: a descriptive study using citation tracking.NIHR open research · 2026Article
- Factors that influence vaccination communication during pregnancy: provider and patient perspectives using the theoretical domains framework.JBI evidence implementation · 2025Article
- Association of antenatal or neonatal SARS-COV-2 exposure with developmental and respiratory outcomes, and healthcare usage in early childhood: a national prospective cohort study.EClinicalMedicine · 2024Article
- Characteristics and outcomes of neonates hospitalised with SARS-CoV-2 infection in the UK by variant: a prospective national cohort study.Archives of disease in childhood. Fetal and neonatal edition · 2024Article
- Perinatal outcomes after admission with COVID-19 in pregnancy: a UK national cohort study.Nature communications · 2024Article
- Multi-organ dysfunction and outcomes in pregnancy associated COVID-19 infection - descriptive review of pathological findings.BMC pregnancy and childbirth · 2024Article
- Article
- Antimicrobial stewardship and targeted therapies in the changing landscape of maternal sepsis.Journal of intensive medicine · 2024Review
- Preterm prelabour rupture of membranes before 23 weeks' gestation: prospective observational study.BMJ medicine · 2024Article
- Critical care, maternal and neonatal outcomes of pregnant women with COVID-19 admitted to eight intensive care units during the wildtype, alpha and delta waves of the pandemic across the North West of England-a retrospective review.Acta obstetricia et gynecologica Scandinavica · 2023Article
- Severe COVID-19 during pregnancy in Sweden, Norway, and Denmark.Acta obstetricia et gynecologica Scandinavica · 2023Article
- Maternal and Perinatal Outcomes of SARS-CoV-2 and Variants in Pregnancy.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2023Article
- Vaccination options for pregnant women during the Omicron period.Journal of reproductive immunology · 2023Review
- Pregnancy outcomes and vaccine effectiveness during the period of omicron as the variant of concern, INTERCOVID-2022: a multinational, observational study.Lancet (London, England) · 2023Observational
- Review
- Article
- Comparison of maternal and neonatal outcomes of COVID-19 before and after SARS-CoV-2 omicron emergence in maternity facilities in Malawi (MATSurvey): data from a national maternal surveillance platform.The Lancet. Global health · 2022Article
- COVID-19 vaccination in pregnancy.American journal of obstetrics and gynecology · 2022Review
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To describe the severity of maternal infection when the omicron SARS-CoV-2 variant (B.1.1.529) was dominant (15 December 2021 to 14 March 2022) and describe outcomes by symptoms and vaccination status. Design: Prospective, national cohort study using the UK Obstetric Surveillance System. Setting: 94 hospitals in the UK with a consultant led maternity unit. Participants: Pregnant women admitted to hospital for any cause with a positive SARS-CoV-2 test. Main outcome measures: Symptomatic or asymptomatic infection, vaccination status by doses before admission, and severity of maternal infection (moderate or severe infection according to modified World Health Organization's criteria). Results: Of 3699 women who were admitted to hospital, 986 (26.7%, 95% confidence interval 25.3% to 28.1%) had symptoms; of these, 144 (14.6%, 12.5% to 17.0%) had a moderate to severe infection, 99 (10.4%, 8.6% to 12.5%) of 953 received respiratory support, and 30 (3.0%, 2.1% to 4.3%) were admitted to an intensive care unit. Covid-19 specific drug treatment was given to 13 (43.3%) of the 30 women in intensive care. Four women with symptoms died (0.4%, 0.1% to 1.1%). Vaccination status was known for 845 (85.6%) women with symptoms; 489 (58.9%) were unvaccinated and only 55 (6.5%) had three doses. Moderate to severe infection was reported for 93 (19.0%) of 489 unvaccinated women with symptoms, decreasing to three (5.5%) of 55 after three doses. Among the 30 women with symptoms who were admitted to intensive care, 23 (76.7%) were unvaccinated and none had received three doses. Conclusion: Most women with severe covid-19 disease were unvaccinated and vaccine coverage among pregnant women admitted to hospital with SARS-CoV-2 was low. Ongoing action to prioritise and advocate for vaccine uptake in pregnancy is essential. A better understanding of the persistent low use of drug treatments is an urgent priority. Trial registration: ISRCTN 40092247.
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