ReviewBMJ medicine2022
Exertional heat stroke: pathophysiology and risk factors.
Review in BMJ medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed.
- Nanocurcumin attenuates brain injury in rats with desert dry‑heat‑induced exertional heat stroke by suppressing TLR4/MyD88/NF‑κB signaling.Molecular medicine reports · 2026Article
- Review
- Demographic Profiles, Clinical Characteristics, and Meteorological Context of Heat-Related Illnesses among Hajj Pilgrims in 2023.Saudi medical journal · 2026Article
- Gastrointestinal microbiota and barrier integrity in individuals who develop exertional heat illness and pair-matched controls: A prospective observational cohort study.Experimental physiology · 2026Article
- Mechanisms and Intervention Strategies for Heat Stroke-Associated Myocardial Dysfunction: A Narrative Review.The western journal of emergency medicine · 2026Review
- Combined single-cell transcriptome and immune repertoire analysis reveals hepatic and renal immune injury by heat stroke.JCI insight · 2026Article
- From Systemic Stress to Ovarian Failure: Heat Stress-Induced Infertility in Pigs as a Model for Reproductive Dysfunction.Current issues in molecular biology · 2026Review
- GPER agonist G1 suppresses neuronal apoptosis mediated by endoplasmic reticulum stress after exertional heat stroke injury.Scientific reports · 2026Article
- Differential Intestinal Epithelial Injury Following Passive and Exertional Hyperthermia.Sports medicine - open · 2026Article
- Temperature-Gradient Transcriptomic Atlas Reveals the PPAR Signaling Pathway Dysfunction in Heat Stroke Induced Liver Injury.FASEB bioAdvances · 2026Article
- Faecal microbiome, gastrointestinal integrity, inflammation and thermoregulation in recent exertional heat illness patients and matched controls.Experimental physiology · 2026Article
- A New Paradigm for Precision Medicine in Heatstroke: From Molecular Subtyping to Targeted Prevention and Treatment.Journal of inflammation research · 2026Review
- Combined heat and exercise stress disrupt gut microbiota and promote microbial translocation.Frontiers in microbiology · 2026Article
- The 2025Lancet regional health. Americas · 2025Review
- [Application of multidisciplinary team diagnosis and treatment model in the management of patients with combined burns and heat stroke].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2025Observational
- Exploring the risk of heat stress in high school pre-season sports training, Johannesburg, South Africa.International journal of biometeorology · 2025Article
- Influence of long-distance trail running on blood hemostasis at the World Mountain Trail Running Championship 2023-a pilot study.Research and practice in thrombosis and haemostasis · 2025Article
- Associations Between Temperature and Location of Injury or Condition Among Heat-Related Emergency Department Visits.GeoHealth · 2025Article
- Impact of moderate environmental heat stress during running exercise on circulating markers of gastrointestinal integrity in endurance athletes.Physiological reports · 2025Article
- Extreme heat risk and the potential implications for the scheduling of football matches at the 2026 FIFA World Cup.International journal of biometeorology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exertional heat stroke, the third leading cause of mortality in athletes during physical activity, is the most severe manifestation of exertional heat illnesses. Exertional heat stroke is characterised by central nervous system dysfunction in people with hyperthermia during physical activity and can be influenced by environmental factors such as heatwaves, which extend the incidence of exertional heat stroke beyond athletics only. Epidemiological data indicate mortality rates of about 27%, and survivors display long term negative health consequences ranging from neurological to cardiovascular dysfunction. The pathophysiology of exertional heat stroke involves thermoregulatory and cardiovascular overload, resulting in severe hyperthermia and subsequent multiorgan injury due to a systemic inflammatory response syndrome and coagulopathy. Research about risk factors for exertional heat stroke remains limited, but dehydration, sex differences, ageing, body composition, and previous illness are thought to increase risk. Immediate cooling remains the most effective treatment strategy. In this review, we provide an overview of the current literature emphasising the pathophysiology and risk factors of exertional heat stroke, highlighting gaps in knowledge with the objective to stimulate future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.