ReviewBMJ medicine2022
Update on the management of upper gastrointestinal bleeding.
Review in BMJ medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Is ibuprofen associated with upper gastrointestinal bleeding? A systematic review and meta-analysis.Inflammopharmacology · 2025Pooled it
- Ultrasound-activated trilayer piezoelectric bio-adhesive for rapid repair and antibacterial treatment of gastrointestinal perforation.Bioactive materials · 2026Article
- Prediction of Blood Transfusion Need and Dose in Patients With Upper Gastrointestinal Bleeding: Retrospective Multicenter Prediction Model Study.JMIR medical informatics · 2026Article
- Dietary mimicry of melena following chocolate cookie ingestion in a patient with colostomy: a case report.Journal of medical case reports · 2026Article
- Comprehensive review on the current management of upper-GI bleed.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Review
- Endoscopic Treatment of Upper Gastrointestinal Bleeding.The Korean journal of helicobacter and upper gastrointestinal research · 2026Review
- Acute Gastrointestinal Bleeding: An Update and a Practical Diagnostic Approach.Diagnostics (Basel, Switzerland) · 2026Review
- Article
- Article
- Efficacy of omeprazole combined with endoscopic hemostasis in the treatment of patients with bleeding peptic ulcers.Medicine · 2026Observational
- Abdominal Compartment Syndrome Following Massive Transfusion in Upper Gastrointestinal Bleeding: A Case Report.Cureus · 2026Article
- Clinical practice patterns in the pre-endoscopic management of individuals presenting with acute upper gastrointestinal bleeding: results of an international survey.Therapeutic advances in gastroenterology · 2026Article
- Gastrointestinal bleeding care across hospital and EMS settings in the Almaty region: a cross-sectional survey of organization, practice, and service capacity.Frontiers in health services · 2026Article
- Association of time to red blood cell transfusion on outcomes in patients with gastrointestinal bleeding.Annals of medicine · 2025Article
- Minutes to Save a Life in Acute GI Bleeding: A Systematic Review of Early vs. Delayed Endoscopy.Cureus · 2025Review
- Variceal Upper Gastrointestinal Bleeding: A Retrospective Cohort of 98 Cases, Historical Comparison, and Updated Management Algorithm.Life (Basel, Switzerland) · 2025Article
- Therapeutic outcomes and predictors of efficacy for endoscopic variceal ligation plus propranolol in liver cirrhosis-related upper gastrointestinal bleeding.World journal of gastrointestinal surgery · 2025Article
- Are Scoring Systems Useful in Predicting Mortality from Upper GI Bleeding in Geriatric Patients?Diagnostics (Basel, Switzerland) · 2025Article
- Machine learning based CAGIB score predicts in-hospital mortality of cirrhotic patients with acute gastrointestinal bleeding.NPJ digital medicine · 2025Article
- Clinical Impact of Red Blood Cell Transfusion Location on Gastrointestinal Bleeding Outcomes: Emergency Department vs. Inpatient Unit.Healthcare (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Upper gastrointestinal bleeding is a common emergency presentation requiring prompt resuscitation and management. Peptic ulcers are the most common cause of the condition. Thorough initial management with a structured approach is vital with appropriate intravenous fluid resuscitation and use of a restrictive transfusion threshold of 7-8 g/dL. Pre-endoscopic scoring tools enable identification of patients at high risk and at very low risk who might benefit from specific management. Endoscopy should be carried out within 24 h of presentation for patients admitted to hospital, although optimal timing for patients at a higher risk within this period is less clear. Endoscopic treatment of high risk lesions and use of subsequent high dose proton pump inhibitors is a cornerstone of non-variceal bleeding management. Variceal haemorrhage results in higher mortality than non-variceal haemorrhage and, if suspected, antibiotics and vasopressors should be administered urgently, before endoscopy. Oesophageal variceal bleeding requires endoscopic band ligation, whereas bleeding from gastric varices requires thrombin or tissue glue injection. Recurrent bleeding is managed by repeat endoscopic treatment. If uncontrolled bleeding occurs, interventional radiological embolisation or surgery is required for non-variceal bleeding or transjugular intrahepatic portosystemic shunt placement for variceal bleeding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.