Evidence map›Paper›PMID 36936495›Full record

ArticleFrontiers in aging neuroscience2023

Role of the subthalamic nucleus in perceiving and estimating the passage of time.

Motoyasu Honma, Fuyuko Sasaki, Hikaru Kamo, Maierdanjiang Nuermaimaiti, Hitoshi Kujirai, Takeshi Atsumi, Atsushi Umemura, Hirokazu Iwamuro, Yasushi Shimo, Genko Oyama and 2 more

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Article in Frontiers in aging neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Motoyasu HonmaDepartment of Medical Physiology, Kyorin University of School of Medicine, Tokyo, Japan.
Fuyuko SasakiDepartment of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Hikaru KamoDepartment of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Maierdanjiang NuermaimaitiDepartment of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Hitoshi KujiraiDepartment of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Takeshi AtsumiDepartment of Medical Physiology, Kyorin University of School of Medicine, Tokyo, Japan.
Atsushi UmemuraDepartment of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan.
Hirokazu IwamuroDepartment of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan.
Yasushi ShimoDepartment of Neurology, Juntendo University Nerima Hospital, Tokyo, Japan.
Genko OyamaDepartment of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Nobutaka HattoriDepartment of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Yasuo TeraoDepartment of Medical Physiology, Kyorin University of School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sense of time (temporal sense) is believed to be processed by various brain regions in a complex manner, among which the basal ganglia, including the striatum and subthalamic nucleus (STN), play central roles. However, the precise mechanism for processing sense of time has not been clarified. To examine the role of the STN in temporal processing of the sense of time by directly manipulating STN function by switching a deep brain stimulation (DBS) device On/Off in 28 patients with Parkinson's disease undergoing STN-DBS therapy. The test session was performed approximately 20 min after switching the DBS device from On to Off or from Off to On. Temporal sense processing was assessed in three different tasks (time reproduction, time production, and bisection). In the three temporal cognitive tasks, switching STN-DBS to Off caused shorter durations to be produced compared with the switching to the On condition in the time production task. In contrast, no effect of STN-DBS was observed in the time bisection or time reproduction tasks. These findings suggest that the STN is involved in the representation process of time duration and that the role of the STN in the sense of time may be limited to the exteriorization of memories formed by experience.

Indexed as

deep brain stimulationParkinson’s diseaserepresentationsubthalamic nucleustemporal sense

Identifiers

PMID36936495
PMCPMC10017994

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.