Evidence map›Paper›PMID 36936386›Full record

ArticleJournal of bone oncology2023

YBX1-interacting small RNAs and

Darrell Green, Archana Singh, Victoria L Tippett, Luke Tattersall, Karan M Shah, Chileleko Siachisumo, Nicole J Ward, Paul Thomas, Simon Carter, Lee Jeys and 6 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Biological Sample Collection to Advance Research and Treatment: A Fight Osteosarcoma Through European Research and Euro Ewing Consortium Statement.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Guideline
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  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Epigenetic Regulation of RUNX2 in Bone Mechanobiology.Results and problems in cell differentiation · 2026
    Review
  11. Transcriptional dynamics of CD8Molecular cancer · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Review
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Darrell GreenBiomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich, UK.
Archana SinghSchool of Biological Sciences, University of East Anglia, Norwich, UK.
Victoria L TippettThe Mellanby Centre for Musculoskeletal Research, Department of Oncology and Metabolism, The University of Sheffield, UK.
Luke TattersallThe Mellanby Centre for Musculoskeletal Research, Department of Oncology and Metabolism, The University of Sheffield, UK.
Karan M ShahThe Mellanby Centre for Musculoskeletal Research, Department of Oncology and Metabolism, The University of Sheffield, UK.
Chileleko SiachisumoBiosciences Institute, Newcastle University, Newcastle, UK.
Nicole J WardSchool of Biological Sciences, University of East Anglia, Norwich, UK.
Paul ThomasSchool of Biological Sciences, University of East Anglia, Norwich, UK.
Simon CarterOrthopaedic Oncology, Royal Orthopaedic Hospital, Birmingham, UK.
Lee JeysOrthopaedic Oncology, Royal Orthopaedic Hospital, Birmingham, UK.
Vaiyapuri SumathiMusculoskeletal Pathology, University Hospitals Birmingham, Royal Orthopaedic Hospital, Birmingham, UK.
Iain McNamaraOrthopaedics & Trauma, Norfolk and Norwich University Hospital, Norwich, UK.
David J ElliottBiosciences Institute, Newcastle University, Newcastle, UK.
Alison GartlandThe Mellanby Centre for Musculoskeletal Research, Department of Oncology and Metabolism, The University of Sheffield, UK.
Tamas DalmaySchool of Biological Sciences, University of East Anglia, Norwich, UK.
William D FraserBiomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich, UK.
University of East Anglia · GBUniversity of Sheffield · GBRoyal Orthopaedic Hospital · GBNewcastle University · GBNorfolk and Norwich University Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary bone cancer (PBC) comprises several subtypes each underpinned by distinctive genetic drivers. This driver diversity produces novel morphological features and clinical behaviour that serendipitously makes PBC an excellent metastasis model. Here, we report that some transfer RNA-derived small RNAs termed tRNA fragments (tRFs) perform as a constitutive tumour suppressor mechanism by blunting a potential pro-metastatic protein-RNA interaction. This mechanism is reduced in PBC progression with a gradual loss of tRNAGly

Indexed as

bone cancerCADD522CADD522, computer aided drug design molecule 522CI, confidence intervalCNV, copy number variantCS, chondrosarcomaCTC, circulating tumour cellDE, differentially expressedES, Ewing sarcomaHD, high definitionHR, hazard ratioiCLIP, individual nucleotide resolution cross-linking and immunoprecipitationmiRNAmiRNA, microRNAmRNA, messenger RNAOS, osteosarcomapiRNA, piwi interacting RNARBP, RNA binding proteinRnl, T4 RNA ligaseRNU6-1, U6 small nuclear 1ROI, region-of-interestsmall RNASNV, single nucleotide variantsRNA, small RNASV, structural varianttRFtRF, transfer RNA fragmenttRNA, transfer RNAysRNA, Y RNA-derived sRNA

Identifiers

PMID36936386
PMCPMC10015236
OpenAlexW4323262568

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read70
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.